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- Ohshima Yoshiyuki
- School of Veterinary Medicine, Azabu University Research Dept. for Experimental Animals
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- Wada Saeko
- School of Veterinary Medicine, Azabu University
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- Tamura Mitshiro
- School of Veterinary Medicine, Azabu University
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- Gotoh Ken
- Research & Development Center, Nihon Nosan Kogyo Co. Ltd.,
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- Kaneko Masahiro
- Research & Development Center, Nihon Nosan Kogyo Co. Ltd.,
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- Funaba Masayuki
- School of Veterinary Medicine, Azabu University
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- Iriki Tsunenori
- School of Veterinary Medicine, Azabu University
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- Hatano Yoshikazu
- Research & Development Center, Nihon Nosan Kogyo Co. Ltd.,
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- Abe Matanobu
- School of Veterinary Medicine, Azabu University
Bibliographic Information
- Other Title
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- ドライキャットフードへのL-シスチン添加による尿の酸性化
- ドライキャットフード エ ノ L シスチン テンカ ニ ヨル ニョウ ノ サンセイカ
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Abstract
This study was conducted to examine the urine-acidifying effect and the possible adverse effects of L-cystine added to dry cat food. Six healthy adult cats, weighing 3.3 kg in average, were divided into 3 groups, and three experimental diets containing 0,2.4, and 4.8% L-cystine were allotted to the 3 groups in a 3×3 Latin square design with 8 d per period. The animals were allowed free access to the diets and water throughout the experiment, and weight gains, food intake, water intake, urine volume, daily amounts of feces were determined during the last 5 d of each period. Urine pH and the number of struvite crystals in urine were determined using fresh urine collected every morning, The remaining urine was used to determine urinary concentrations of Mg, P, urea-N, ammonia-N, creatinine and free amino acids, and the struvite activity products was given by [Mg2+] [NH4+] [PO43-]. Conversely, blood samples were take from the jugular vein on the last day of each period, and were used to determine hematocrit, and the plasma concentrations of total protein, urea-N, ammonia-N, creatinine, and free amino acids. Glomerular filtration rate was determined on the basis of creatinine concentrations in the plasma and urine. As a result, it was shown that the urine-acidifying effect of L-cystine is almost equivalent to DL-methionine (DL-Met)containing the same level of S, but is not so toxic as DL-Met. However, cystine imbalance could occur in cats, because food intake was depressed by dietary supplementation of excess L-cystine without a significant decrease in the body weight. The level of L-cystine adequate for the urine acidification in cats was considered to be less than 2.4% of dry cat food, but further studies are needed concerning this matter. Although the dietary supplementation of L-cystine did not result in an increased incidence of cystinurea or cystine urolithiasis, present results suggested a peculiarity in cats as for the urinary excretion of dibasic amino acids, especially cystine, lysine, and arginine.
Journal
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- Journal of Pet Animal Nutrition
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Journal of Pet Animal Nutrition 6 (2), 64-73, 2003
Japanese Society of Pet Animal Nutrition
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Details 詳細情報について
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- CRID
- 1390001205460403840
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- NII Article ID
- 130004991138
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- NII Book ID
- AA11293143
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- NDL BIB ID
- 6555659
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- ISSN
- 13443763
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed