Prevention of the Symptomatic vasospasm in Poor Risk Aneurysmal Patients by Ticlopidine, Albumin and Nicardipine (TAN-Therapy)
-
- FUJITA Katsuzo
- Department of Neurosurgery, Kobe University School of Medicine
-
- SHIRAKUNI Takayuki
- Department of Neurosurgery, Kobe University School of Medicine
-
- LINN Xianbin
- Department of Neurosurgery, Kobe University School of Medicine
-
- ASADA Masahiro
- Department of Neurosurgery, Kobe University School of Medicine
-
- EHARA Kazumasa
- Department of Neurosurgery, Kobe University School of Medicine
-
- TAMAKI Norihiko
- Department of Neurosurgery, Kobe University School of Medicine
-
- MATSUMOTO Satoshi
- Department of Neurosurgery, Kobe University School of Medicine
Bibliographic Information
- Other Title
-
- 重症クモ膜下出血後のsymptomatic vasospasm に対する ticlopidine, albumin, nicardipineの併用療法(TAN-therapy) の有効性について
- -血液凝固系および中大脳動脈血流速度からの検討-
Abstract
The pathogenesis of symptomatic vasospasm following subarachnoid hemorrhage is still unclear. To clarify this, we analyzed changes of blood coagulation activities between 65 poor risk aneurysmal patients treated by a combination with ticlopidine, albumin and nicardipine (so called TAN therapy) and in 52 untreated patients with symptomatic vasospasm. The hypercoagulable state was scored according to the Disseminated Intravascular Coagulation (DIC) scoring system. Our clinical studies showed that severe SAH following aneurysmal rupture caused the hypercoagulable state. There were good correlations between the degree of hypercoagulation and the severity of the symptomatic vasospasm. TAN therapy reduced the DIC scores by antiplatelet agent and prevented the occurrence of the symptomatic vasospasm in severe SAH. These facts support the beneficial effects of TAN therapy in prevention of symptomatic vasospasm in severe SAH.
Journal
-
- Surgery for Cerebral Stroke
-
Surgery for Cerebral Stroke 19 (2), 247-251, 1991
The Japanese Society on Surgery for Cerebral Stroke
- Tweet
Details 詳細情報について
-
- CRID
- 1390001205464291328
-
- NII Article ID
- 130004668275
-
- ISSN
- 09145508
-
- Text Lang
- ja
-
- Data Source
-
- JaLC
- Crossref
- CiNii Articles
-
- Abstract License Flag
- Disallowed