A study on the association between pancreatic juice reflux into the biliary tract and cholangiocarcinogenesis

DOI

Bibliographic Information

Other Title
  • 膵液の胆道内逆流と発癌との関係
  • a study in rat models of bile duct dilatation
  • 胆管拡張モデルにおける検討

Abstract

To study the association between pancreatic juice reflux into the biliary tract and cholangiocarcinogenesis, we used dibutyltin dichloride (DBTC) -treated rats as our model of bile duct dilatation. Moreover, we compared the DBTC-treated model with rats with bile ducts ligated near the duodenum or at the porta hepatica. The epithelium of the extra hepatic bile duct in the DBTC-treated rats and the rats with ligation near the duodenum exhibited cell proliferation and COX-2expression. Since these changes may be caused by the reflux of pancreatic juice into the biliary tract, the models seemed to closely resemble pancreaticobiliary maljunction in man. Furthermore, the increase in COX-2 expression in both models suggests that there is an association between the pancreatic juice reflux and cholangiocarcinogenesis.

Journal

  • Tando

    Tando 19 (1), 16-22, 2005

    Japan Biliary Association

Keywords

Details 詳細情報について

  • CRID
    1390001205465079040
  • NII Article ID
    130004675751
  • DOI
    10.11210/tando1987.19.1_16
  • ISSN
    09140077
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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