Histopathological study on dibutyltin dichloride-induced bile duct dilatation in rats

DOI 1 Citations 9 References
  • KUWAYANIA Chitose
    Department of Pathology, Juntendo University, School of Medicine (Tokyo)
  • MIYAUCHI Makoto
    Department of Pathology, Juntendo University, School of Medicine (Tokyo)
  • KAKINUMA Chihaya
    Department of Pathology, Juntendo University, School of Medicine (Tokyo)
  • ABE Hiroshi
    Department of Pathology, Juntendo University, School of Medicine (Tokyo)
  • SUZUKI Fujihiko
    Central Laboratory, Juntendo University Urayasu Hospital (Urayasu)
  • SUDA Koichi
    Department of Pathology, Juntendo University, School of Medicine (Tokyo)

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Other Title
  • ラットにおける dibutyltin dichloride 誘発胆管拡張症の病理組織学的検討

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Abstract

Male Lewis rats treated intravenously with a single dose of dibuthyltin dichloride (DBTC)showed epithelial damage in the extrahepatic bile duct, chronic inflammation, and sequential obstruction and cystic dilatation of the bile duct. In the liver, cholangiolitis and proliferation of bile ducts was characteristic, and the animals with marked inflammation showed cirrhosis-like structures. Taking these facts together, we consider these DBTC treated rats to be a model of bile duct dilatation or biliary cirrhosis found in humans.<BR>Bile duct dilatation in humans is thought to be related to an abnormal pancreatico-choledochal duct junction. Also in this model, one of the cause of pathologic condition may owe to the anastomosis of pancreatic duct and bile one. So we may have a clue to solving the mechanism whereby bile duct dilatation occurs in human.

Journal

  • Tando

    Tando 16 (2), 94-99, 2002

    Japan Biliary Association

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