Inhibitory effects of Dai-saiko-to (TJ-8) on the cholesterol gallstone formation in hamsters

DOI
  • AIHARA Naoki
    First Department of Internal Medicine, Hiroshima University School of Medicine
  • TAZUMA Susumu
    First Department of Internal Medicine, Hiroshima University School of Medicine
  • OHYA Toshihide
    First Department of Internal Medicine, Hiroshima University School of Medicine
  • HATSUSHIKA Sumie
    First Department of Internal Medicine, Hiroshima University School of Medicine
  • YAMASHITA Yoshifumi
    First Department of Internal Medicine, Hiroshima University School of Medicine
  • HORIKAWA Kazuhiko
    First Department of Internal Medicine, Hiroshima University School of Medicine
  • OCHI Hidenori
    First Department of Internal Medicine, Hiroshima University School of Medicine
  • TERAMEN Kazushi
    First Department of Internal Medicine, Hiroshima University School of Medicine
  • HIRANO Tadamichi
    First Department of Internal Medicine, Hiroshima University School of Medicine
  • MIURA Hiroyuki
    First Department of Internal Medicine, Hiroshima University School of Medicine
  • SASAKI Masatoshi
    First Department of Internal Medicine, Hiroshima University School of Medicine
  • KAJIYAMA Goro
    First Department of Internal Medicine, Hiroshima University School of Medicine

Bibliographic Information

Other Title
  • コレステロール胆石形成モデルにおける大柴胡湯 (TJ-8) による胆石形成抑制効果
  • グルコース食投与ハムスターを用いて

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Description

The effect of Dai-saiko-to (TJ-8) on the cholesterol gallstone formation was investigated in hamsters fed a high glucose diet, as an experimental model for cholesterol gallstone formation. Animals were fed a normal chow or 75% (w/w) glucose diet (lithogenic diet) with or without 1% Dai-saiko-to (w/w) for 4 weeks. The gallstone incidence was 71% in animals fed a high glucose diet, whereas no stones were formed in the other groups. Thus, cholesterol gallstone formation was prevented by the treatment with Dai-saiko-to. The increase in tissue cholesterol (serum, liver, bile)by high glucose feeding was significantly suppressed by Dai-saiko-to. Further, the appearance rate of cholesterol monohydrate crystal in bile or on the surface of gallbladder was significantly reduced in animals treated with Dai-saiko-to. These findings suggest that Dai-saiko-to prevents cholesterol gallstone formation by reducing the bile cholesterol saturation index, and that the reduction in intestinal cholesterol absorption and hepatic cholesterol synthesis may attribute to such an action of Dai-saiko-to.

Journal

  • Tando

    Tando 8 (1), 9-13, 1994

    Japan Biliary Association

Keywords

Details 詳細情報について

  • CRID
    1390001205467640960
  • NII Article ID
    130004675984
  • DOI
    10.11210/tando1987.8.1_9
  • ISSN
    09140077
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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