STUDIES ON NEW RENAL IMAGING AGENT—<sup>99</sup>mTC-MALATE

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  • Ueda Masataka
    Depertment of Urology, The Jikei University School of Medicine Tokyo

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Other Title
  • 新しい腎イメージング剤<sup>99m</sup>Tc-malate に関する研究
  • 新しい腎イメージング剤99mTc-malateに関する研究
  • アタラシイ ジン イメージングザイ99m Tc malate ニカンスルケンキ
  • STUDIES ON NEW RENAL IMAGING AGENT&mdash;<sup>99</sup>mTC-MALATE

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Abstract

With the aim of developing new renal imaging agents for γ-cameras, three types of compounds—cysteine acetazolamide complex, malic acid, and salicyluric acid—were selected and labeled with 99mTc by e-lectrolysis.<br>These new renal imaging agents—99mTc-cysteine acetazolamide complex (TCAC), 99mTc-malate and 99mTc-salicylurate—were studied with regard to renal images of rabbits and normal humans. In animal experments using rabbits, renal images obtained with 99mTc-salicylurate proved better than the other agents, but in experiments with humans 99mTc-malate gave clearer images than the other. From pharmaceutical discussion it was understood that 99mTc-malate (pH 5.0) is excellent in labeling yield (99%) and chemical stability and that malic acid is nontoxic metabolite in vivo. The half time of 99mTc-malate disappearance in human blood was 17 minutes on the average. The excretion rate in urine was 36±6.05% of the dosage at 1 hour, 44±3.41% at 2 hours and 50±5.62% at 3 hours after intravenous injection.<br>Since the possibility for clinical use of 99mTc-malate was suggested from the above results, renal imaging was performed on 57 cases with urological renal disorders. In renal imaging, vascular and functional phases were examined; also urinary tract images were discussed. The vascular phase was obtained at 10-20 seconds after intravenous injection (at 10-30 seconds in old patients). The functional phase began to be obtained at 10 minutes after injection, and clearest images were obtained at 60 minutes and thereafter. In the case of obstructive uropathy the urinary tract was observed at 10-30 minutes after intravenous injection. In the case of renal failure when serum creatinine was 4.5 mg/dl or over, hardly any renal images were obtained.<br>The above-mentioned results show that 99mTc-malate is useful as renal imaging agent for renal screeing tests.

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