A STUDY ON ALDOLASE ACTIVITY AND ISOZYME PATTERN OF THE BLADDER TUMOR

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  • Tanaka Reitaro
    Department of Urology, University of Okayama, School of Medicine

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  • 膀胱癌のアルドラーゼ活性並びにアイソザイムパターンに関する研究
  • ボウコウガン ノ アルドラーゼ カッセイ ナラビニ アイソザイムパターン ニ カンスル ケンキュウ

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Aldolase activities and isozyme patterns of mucous membrane and tumor tissue of the bladder were studied in order to investigate their enzymochemical characteristics and forecast recurrence of the tumors.<br>Results were as follows:<br>1) The average fructose-1, 6-diphosphate (FDP) activity of normal mucous membrane of the bladder was 7.6±1.3U/g protein and the value of the tumor tissues was 43.7±5.8U/g protein.<br>Then FDP activity of the latter is 5.8 folds higher than the former.<br>2) The average fructose-1-phosphate (FlP) activity of bladder tumors was 4.2±0.8U/g protein, while no FlP activities was assayed in normal mucous membrane of the bladder.<br>3) The average ratio of FDP/FlP was 16.3±2.0 in bladder tumors.<br>4) The FDP activities were higher in large sized tumors than in medium sized tumors.<br>5) No relationship was found between FDP activities and number, grade or stage of bladder tumors.<br>6) There was an increasing tendency of aldolase C fraction in large sized tumors but not in medium sized tumors.<br>7) No relationship was found between aldolase isozyme patterns and number, grade or stage of bladder tumors.<br>8) There was an increasing tendency of aldolase C fraction in bladder tumors of high FDP activities compared with those of low FDP activities.<br>9) No relationship was found in bladder tumors between FlP activities or FDP/FlP activity ratios and isozyme patterns.<br>10) No relationship was found between recurrences of bladder tumor after the operation and the FDP activities or the aldolase isozyme patterns of the tumor.<br>11) The aldolase A and A3C hybrid were found in many bladder tumors, while the aldolase A and A3B hybrid were found in normal mucous membranes. It was suggested that a disordered pattern on gene expression occurred during carcinogenesis of the bladder.

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