Bilirubinに關する2, 3の問題 (間接竝に直接ビリルビンの本態竝に其の特性の解析)

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タイトル別名
  • A Few Problems Concerning Bilirubin in the Living Body. (An Analysis of the True Nature and Properties of Indirect and Direct Bilirubin)
  • Bilirubinに関する2・3の問題-間接並に直接ビリルビンの本態並に其の特性の解析-
  • Bilirubin ニ カンスル 2 3 ノ モンダイ カンセツ ナラビニ チョクセツ ビリルビン ノ ホンタイ ナラビニ ソノ トクセイ ノ カイセキ

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説明

The indirect bilirubin of hemolytic icterus serum is a dibasic acid with the propionic acid side chain in the form of free acid radicals, while the direct bilirubin contained in mechanical jaundice serum forms an ester or salt on the propionic acid side chain These facts were determined by means of saponification with 5% alcoholic potash and hydrolysis by hydrochloric acid.<BR>The greater part of the direct bilirubin in the living body is in ester form, while a small portion in salt form is contained in the bile and urine.<BR>The hepatic cell mainly performs the esterification of indirect bilirubin, though this function is also carried out to some extent by the pulmonary, dermal and cerebral tissues. The ester thus formed is probably a methyl ester.<BR>The alcohol used in quantitative determination of bilirubin serves to form direct bilirubin from the indirect by forming an ester, while coffeine gives the same result by producing a salt. Formic acid and glacial acetic acid form double salts on the first and fourth basic pyrrolenine nuclei, while acetone condenses to form mesityl oxide, which by addition to the intermediate methene (-CH2-), produces direct bilirubin from indirect bilirubin.

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