A Possible Case of Anti-NMDA-Receptor Encephalitis with Psychiatric Symptoms and Cognitive Impairment

DOI Web Site Web Site 2 References
  • Akagi Mariko
    National Hospital Organization Kikuchi Hospital Department of Neuropsychiatry, Kumamoto University
  • Yuuki Seiji
    Department of Neuropsychiatry, Kumamoto University
  • Hidaka Yousuke
    Medical Center of Kumamoto Prefectural Heart
  • Kajio Yuusuke
    Department of Neuropsychiatry, Kumamoto University
  • Kashiwagi Hiroko
    Department of Psychiatry, National Center of Neurology and Psychiatry
  • Ikeda Manabu
    Department of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University

Bibliographic Information

Other Title
  • 発熱後に精神症状や認知機能低下を伴った抗NMDA受容体脳炎が疑われた１例
  • ハツネツ ゴ ニ セイシン ショウジョウ ヤ ニンチ キノウ テイカ オ トモナッタ コウNMDA ジュヨウタイ ノウエン ガ ウタガワレタ 1レイ

Search this article

Abstract

<p>Anti-NMDA-receptor encephalitis is a relatively rare disease which often demonstrates characteristic psychiatric symptoms similar to schizophrenia. Clinical improvement can be expected when both an early diagnosis and early treatment can be achieved. We herein report a possible case of anti-NMDA-receptor encephalitis. The patient was a67-year-old man. He had been hospitalized due to the onset of acute enteritis. Eight weeks later, he started to demonstrate abnormal behavior, such as removing excrement out from his anus with his fingers and frequently going back and forth between the restroom and his bed. He also became delusional and feared that he might be beaten when he went outside, and that his wife was not his real wife. He showed various types of cognitive impairment and his MMSE score was 18/30. In a spinal fluid test, anti-glutamate receptor antibody was positive.According to these findings, anti-NMDA-receptor encephalitis was suspected and steroid treatment was thereforestarted for him. The subsequent improvement in his psychiatric symptoms and cognitive impairment was remarkable and his MMSE score improved to 25/30. Cases of anti-NMDA receptor encephalitis which develop in association with infectious diseases, including the enteritis, have been reported. As a result, when cases suddenly develop psychiatric symptoms and cognitive impairment after infection, then the possibility of anti-NMDA receptor encephalitis should therefore be included in the differential diagnosis.</p>

Journal

References(2)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top