Novel Flow Cytometry Method for Detecting Complement C1q Bound to Anti-blood Group A/B-IgG Antibody in ABO-incompatible Renal Transplantation

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  • Ishizuka Tsutomu
    Division of Transplant Immunology, Central Clinical Laboratories, Tokyo Women’s Medical University
  • Yasuo Mineko
    Division of Transplant Immunology, Central Clinical Laboratories, Tokyo Women’s Medical University
  • Kobayashi Yuri
    Division of Transplant Immunology, Central Clinical Laboratories, Tokyo Women’s Medical University
  • Miura Hitomi
    Division of Transplant Immunology, Central Clinical Laboratories, Tokyo Women’s Medical University
  • Kai Kotaro
    Department of Surgery, Kidney Center, Tokyo Women’s Medical University
  • Iwadoh Kazuhiro
    Department of Surgery, Kidney Center, Tokyo Women’s Medical University
  • Murakami Toru
    Department of Surgery, Kidney Center, Tokyo Women’s Medical University
  • Kitajima Kumiko
    Department of Surgery, Kidney Center, Tokyo Women’s Medical University
  • Nakajima Ichiro
    Department of Surgery, Kidney Center, Tokyo Women’s Medical University
  • Fuchinoue Shohei
    Department of Surgery, Kidney Center, Tokyo Women’s Medical University

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  • 補体C1qを用いた血液型抗A/B-IgG抗体検出の有用性

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It has been widely believed that it is critical to remove as much anti A/B blood group antibody as possible before ABO incompatible renal transplantation (ABOI-RTx) for renal graft survival. We, however, report a rare case that implied a presence of hyperacute rejection in ABOI-RTx leading to graft loss, in a way, regardless of titers of blood group antibody before transplantation.<br>We newly developed a method for measuring a complement-fixing ability of anti A/B blood group IgG antibody to elucidate an immunological mechanism of how anti A/B blood group antibody works in ABOI-RTx. Results of such measurements revealed that a high positive rate of complement-fixing ability of anti A/B IgG antibody was predictive of poor graft survival or graft loss. This method, therefore, might turn out to be an important laboratory test before ABOI-RTx.

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