Genetic analysis of HLA class II polymorphism in Japanese patients with sarcoidosis

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  • Kobayashi Akira
    Dept. Microbiology and Immunology, Hamamatsu Univ. School of Medicine Diagnostic Technology Laboratodes, Chugai Pharm. Co. Ltd.
  • Toyoshima Mikio
    Dept. Microbiology and Irmunology, Showa Univ. School of Medicine
  • Yoshitomi Jun
    Dept. Microbiology and Irmunology, Showa Univ. School of Medicine
  • Senda Kingo
    Dept. Microbiology and Irmunology, Showa Univ. School of Medicine
  • Matsubara Koichi
    Diagnostic Technology Laboratodes, Chugai Pharm. Co. Ltd.
  • Koide Yukio
    Dept. Microbiology and Immunology, Hamamatsu Univ. School of Medicine
  • Satoh Atsuhiko
    Dept. Microbiology and Irmunology, Showa Univ. School of Medicine
  • O. Yoshida Takato
    Dept. Microbiology and Irmunology, Showa Univ. School of Medicine

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  • 日本人サルコイドーシス患者のHLAクラスII-DRB1, -DQB1, -DPB1各対立遺伝子のDNAタイピング

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<p> Fifty three Japanese patients with sarcoidosis were typed for HLA-DRB1,-DQB1,-DPB1 alleles. Specific region of DRB1, DQB1, DPB1 genes were amplified enzymatically by PCR method and transcription mediated amplification. Amplified DNA and RNA were detected with chemiluminescence labeled sequence specific oligonucleotide probes. We found significantly increased frequency of DRB1^* 0803 (P＜0.00005) and DQB1^* 0601(P＜0.002) in the patient group. Then in the male patient group, we found significantly increased frequency of DRB1^* 1502, ^* 0803, DQB1^* 0601 or^* 0402, and in the female patient group, we found that she frequencies of DRB1^* 0405,^* 0803, DQB1^* 0601 and^* 0401 were increased significantly.</p>

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