Effects of Hepatic Injury on Blood Pressure, Fibrinoid Necrosis and Cerebral Hemorrhage, in Experimental Renal Hypertension

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  • 実験的高血圧症における血圧, 血管壊死及び腦出血に及ぼす肝障害の影響
  • 実験的高血圧症における血圧,血管壊死及び脳出血に及ぼす肝障害の影響
  • ジッケンテキ コウケツアツショウ ニ オケル ケツアツ , ケッカン エシ オヨビ ノウシュッケツ ニ オヨボス カン ショウガイ ノ エイキョウ

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Abstract

Experimental renal hypertention was produced by the application of a Goldblatt clamp of 0.7 cm on the right renal artery and two weeks later placing a clamp of 0.9 cm on the left artery.Then tetrachloromethane was injected to this hypertensive rabbits, and experimental hepatic injury was produced. According to the time of injection, this hypertensive rabbits were divided into two groups.A-group. : Tetrachloromethane was injected between the operations on the right side and on the left side.B-group. : Tetrachloromethane was injected after the operation on both sides.Those rabbits received only Goldblatt operation served as control.The effect of hepatic injury on the blood pressure, vascular fibrinoid necrosis and cerebral hemorrhage by the experimental rabbits was observed.Results were as follows : 1) By the hepatic injury, rise of the blood pressure was inhibited in A-group, and the blood pressure decreased in B-group. A-group kept low blood pressure longer time than B-group.2) By the hepatic injury, the appearance of vascular fibrinoid necrosis was inhibted. In A- and B-group, the acute form of vascular fibrinoid necrosis was observed only in a few cases.3) By the hepatic injury, the occurrence of the cerebral hemorrhage was decreased. A location of the cerebral hemorrhage was more frequent in the cerebral meninx in A- and B-group.4) The stronger the hepatic injury, a rise of the blood pressure was more inhibited, and the appearance of vascular fibrinoid necrosis and cerebral hemorrhage was more decreased.

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