A Study on Experimental Cerebral Haemorrhage in Rabbits by the Modification of Goldblatt's Method

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  • Glodblatt変法による実験的家兎腦出血の研究
  • Goldblatt変法による実験的家兎脳出血の研究
  • Goldblatt ヘンポウ ニ ヨル ジッケンテキ カト ノウシュッケツ ノ ケンキュウ

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Abstract

1. Using rabbits weighing about two kilograms, cerebral massive haemorrhages were produced by experimental renal hypertension with modified Goldblatt's method.2. Various sizes of U-shaped silver clamps were used in order to constrict the renal main artery. Cerebral massive haemorrhages were produced most frequently in the moderately constricted group. By this method, fifty per cent of the experimented animals showed cerebral massive haemorrhages.3. Alkaline phosphatase histochemically demonstrable in the renal tubules was decreased in variable degrees by ischemia resulted from the constriction of the renal main artery. And in the rabbits, which showed cerebral massive haemorrhages, the degree of its decrease was mostly severe in the right kidney (first operated side) and moderate or slight in the left (secondly operated side).4. There is no certain relationship between the incidence of hypertension and arteriolar fibrinoid necrosis in various organs of the experimented animals.5. Arteriolar fibrinoid necrosis was observed in all of the haemorrhagic brains, however, there were some which had no haemorrhage but did show arteriolar fibrinoid necrosis in the cerebral parenchym.6. Combination of hypertension and arteriolar fibrinoid necrosis in the brain would be an important factor to produce cerebral massive haemorranges in these experimented animals.7. Acid mucopolysaccharides were not demonstrated histochemically in the acute stage of necrotic arteriolar wall, but they could be seen in the subacute and chronic phases. Long survived animals in this experiment showed necrotic arterioles in various stages. This finding indicates the fact that arteriolar fibrinoid necrosis did not appear at a definite time but could appear successively, by some unknown agents, during the period of survival.8. In human autopsy cases with hypertensive cerebral haemorrhages, arterial or arteriolar fibrinoid necrosis was seen, not infrequently, in the brain as well as in other organs, and these cases had never showed any clinical signs of malignant hypertension.9. It is strongly suggested that human hypertensives might show, in some instances, cerebral haemorrhage, following the necrotizing process and consequent rupture of the cerebral arteries or arterioels.

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