冠靜脈洞カテーテル法による心筋新陳代謝に関する研究(第1報) : 心臓神経の影響

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  • Study on the Cardiac Metabolism by the Method of Coronary Sinus Catheterization (I) : PART I. THE INFLUENCE OF THE CARDIAC NERVE
  • 冠静脈洞カテーテル法による心筋新陳代謝に関する研究-1-
  • カン ジョウミャクドウ カテーテルホウ ニ ヨル シンキン シンチンタイシャ ニ カンスル ケンキュウ 1

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It is conceivable that the cardiac nerve has some influence on the metabolism of myocardium. In the study of the nervous control of the coronary circulation, recently it has been stressed that the secondary alteration of the coronary flow due to the change of the metabolism of the myocardium by the cardiac nerve has to be taken into consideration.Using the method of coronary sinus catheterization established by Goodale, the author studied the influence of the stimulation of cardiac nerve on the coronary arteriovenous difference of the concentration of oxygen, carbon dioxide, pyruvic acid, lactic acid and glucose in the naturally pulsating heart of the dog.Method : Coronary sinus catheterization was performed in normal anaesthetized dog. Peripheral part of the cut vagus nerve and stellate ganglion were stimulated electrically for 10 minutes. The blood sample was taken from the coronary sinus and from the femoral artery before and during the stimulation and the arterio-venous difference of the concentartion of each substance was studied.Result : 1) By the stimulation of the vagus nerve, coronary arterio-venous difference of oxygen and lactic acid decreased, that of glucose increase while that of carbon dioxide and pyruvic acid showed no definite tendency.2) By the stimulation of the sympathetic nerve, coronary arterio-venous difference of oxygen, carbon dioxide and lactic acid increased and that of pyruvic acid and glucose showed no tendency.According to Fick's principle, the consumption of the substance by the myoacardium is difined by multipling the coronary arterio-venous difference by coronary flow. It is shown that the coronary flow increases by the sympathetic stimulation and decreases by the vagal stimulation. From the result obtained the author reached the following conclusions.1) By vagal stimulation, the consumption of the oxygen and lactic acid decreses, the utilization of glucose increases and the anaerobic declination of the gaseous metabolism was observed.2) By sympathetic stimulation, the consumption of oxygen and lactic acid increaes and the aerobic declination of the gaseous metabolism was observed.

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