STUDIES ON THE COMBINATION ACTION OF SISOMICIN, DIBEKACIN AND CEFOTETAN, CEFOTAXIME, LATAMOXEF, CEFSULODIN AGAINST ESCHERICHIA COLI, SERRA TIA MARCESCENS AND PSEUDOMONAS AERUGINOSA
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- SAITO MASATO
- Department of Microbiology, Kyoto College of Pharmacy
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- AZUMA KYOKO
- Department of Microbiology, Kyoto College of Pharmacy
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- NISHINO TAKESHI
- Department of Microbiology, Kyoto College of Pharmacy
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- TANINO TERUO
- Department of Microbiology, Kyoto College of Pharmacy
Bibliographic Information
- Other Title
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- Escherichia coli, Serratia marcescens及びPseudomonas aeruginosaに対するSisomicin, DibekacinとCefbtetan, Cefotaxime, Latamoxef, Cefsulodin間の併用に関する細菌学的研究
Abstract
The combined actions of sisomicin (SISO), dibekacin (DKB) and cefotetan (CTT), cefotaxime (CTX), latamoxef (LMOX), cefsulodin (CFS) against E coil KC-14, S. marcescens T-55 and P. aeruginosa E-2 were studied. The following results, were obtained.<BR>1. The combination of SISO-CTT, SISO-CTX, SISO-LMOX, SISO-CFS, DKB-CTT, DKB-CTX, DKBLMOX and DKB-CFS using the checker board dilution method on E. coli KC-14, S. marcescens T-55, P. aeruginosa E-2 were found to have a synergistic effect and the minimum FIC index values were 0.26-0.50 for SISO and 0.28, w 0.75 for DKB, respectively.<BR>2. With the killing kinetic method, all combinations tested showed a synergistic effect.
Journal
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- The Japanese Journal of Antibiotics
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The Japanese Journal of Antibiotics 36 (10), 2833-2843, 1983
Japan Antibiotics Research Association