EXPERIMENTAL TRIAL CONCERNING THE EFFECT OF ACETYLSPIRAMYCIN ON FERTILIZED EGGS

  • SUZUKI SHUETSU
    Department of Obstetrics and Gynecology, School of Medicine,Keio University
  • KAMATA KOHACHI
    Department of Pharmacology, School of Pharmacy,Kitasato University

Bibliographic Information

Other Title
  • Acetylspiramycin の受精卵に及ぼす影響に関する実験的研究

Abstract

Growth of fertilized mouse eggs treated with acetylspiramycin (ASPM) for 24 hours in their diplophase and octaplophase was observed morphologically.Changes in function of the fertilized cells in growth process were also examined,determining cell counts,mitotic index,and sister chromatid exchange as indices.<BR>These indices were all inhibited after treatment with ASPM. However, it seems that the effect was induced by H2SO4 which was used as solvent rather than by ASPM because growth inhibition and functional changes of cells were also caused by H2SO4.<BR>Therefore, it is thought that ASPM, at the concentration of 3-10μg/ml,has little effect on the development of fertilized eggs.

Journal

Details 詳細情報について

  • CRID
    1390001205490055680
  • NII Article ID
    130004393895
  • DOI
    10.11553/antibiotics1968b.36.1562
  • COI
    1:CAS:528:DyaL3sXlsFWkt7w%3D
  • ISSN
    21865477
    03682781
  • PubMed
    6655800
  • Text Lang
    ja
  • Data Source
    • JaLC
    • PubMed
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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