FUNDAMENTAL AND CLINICAL STUDIES OF LATAMOXEF IN INTESTINAL SURGERY

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  • 下部消化管手術時におけるLatamoxefの基礎的・臨床的検討
  • カブ ショウカカン シュジュツジ ニ オケル Latamoxef ノ キソテキ

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Abstract

After the intravenous administration of 1.0g of latamoxef (LMOX), the concentration of LMOX were determined in normal intestinal tissue and serumn of 17 patients underwent surgery for intestinal problems, and the mesults obtained were as follows.<BR>1. At 60-150 minutes after administration, the levels of LMOX were 37.5-26.3μg/ml in serum and 14.8-10.5μg/g in normal intestinal tissues.This values were enough to inhibit the growth of Gram-negative bacteria caused for some postoperative wound infections.<BR>2. For intmavenous administration of 1.0g of LMOX just before operation, no wound infection was observed in 13 patients with large intestinal cancer and 4 patients with benign intestinal disease.

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