BASIC AND CLINICAL STUDIES ON CEFSULODIN FOR THE OTORHINOLARYNGOLOGICAL INFECTIONS

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  • FURUTA SHIGERU
    Department of Otorhinolaryngology, School of Medicine, Kagoshima University
  • FUKUDA KATSUNORI
    Department of Otorhinolaryngology, School of Medicine, Kagoshima University
  • OHHORI YASOICHI
    Department of Otorhinolaryngology, School of Medicine, Kagoshima University
  • OGAWA KAZUAKI
    Department of Otorhinolaryngology, School of Medicine, Kagoshima University
  • IIDA FUMIKO
    Department of Otorhinolaryngology, School of Medicine, Kagoshima University
  • OHYAMA MASARU
    Department of Otorhinolaryngology, School of Medicine, Kagoshima University

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Other Title
  • 耳鼻咽喉科感染症におけるCefsulodinの基礎的, 臨床的研究
  • ジビ インコウカ カンセンショウ ニ オケル Cefsulodin ノ キソテ

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Abstract

Basic and clinical studies on cefsulodin (CFS) for treatment of infectious diseases in otorhinolaryngolo gical field were performed and the following results were obtained.<BR>1.The peak values in the serum levels of CFS were 18.7μg/m in0.5g and 43.0μg/ml in 1g at 30 minutes after a single intravenous injection. CFS was rapidly excreted from the blood after injection and was detected a little amount in serum at 6 hours after drug injection.<BR>2.The transference of drug into tonsilla palatina and the mucous membrane of maxillary sinus was relatively rapid and good.<BR>3. Chemotherapeutic results were excellent in 2 patients, good in 3 and poor in 2 with the infectious diseases in otorhinolaryngological field.<BR>4.No adverse effect nor abnormal values in laboratory findings were seen in every patients.

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