CLINICAL STUDY OF CEFOXITIN IN CHRONIC RESPIRATORY TRACT INFECTIONS: EVALUATION IN POORLY RESPONDING CASES TO OTHER ANTIBIOTICS

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  • HIRAGA YOMEI
    Department of Respiratory Disease, Sapporo Hospital of Japanese National Railways
  • ABE MASATSUGU
    Department of Respiratory Disease, Hakodate Municipal Central Hospital
  • KIKUCHI KOHKI
    Department of Respiratory Disease, Sapporo Hospital of Japanese National Railways
  • NAKAHASHI MASARU
    Department of Respiratory Disease, Sapporo Hospital of Japanese National Railways

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  • 他剤無効の慢性呼吸器感染症に対するセフォキシチンの臨床的研究
  • タザイ ムコウ ノ マンセイ コキュウキ カンセンショウ ニ タイスル セフォ

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The therapeutic efficacy of cefoxitin (CFX) in chronic respiratory tract infection was evaluated in patients who poorly responsed to other antibiotics.<BR>To 20 patients, CFX was administered 2g b.i.d. intravenously by drip infusion.Clinical efficacy was judged based on the criteria by score.<BR>1.Bacterial elimination rate with CFX was 73.7%.<BR>2.A clinical cure rate of 80.0% was obtained by doctors in charge.<BR>3.According to the score assessment, the overall clinical effectiveness rate was 60.0%, clinical symptom cure rate was 85.0% and improvement rate of X-ray findings was 55.0%.<BR>4. Usefulness rate which was assessed by clinical effect and side effect was 70.0%.<BR>5.No side effects and abnormal laboratory findings were observed in this study.<BR>We used the new antibiotic CFX in patients with chronic respiratory tract infections who responsed poorly to other antibiotics and obtained satisfactory results.Especially CFX indicated more effective possibility in cases from whom Gram-negative bacilli were isolated.

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