CONCENTRATION OF CEFOTIAM IN THE HUMAN BONE MARROW FLUID AND BONE TISSUE

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  • KIKUCHI SHIN-ICHI
    Department of Orthopaedic Surgery, Japan Red Cross Medical Center
  • HOSHIKA ICHIRO
    Department of Orthopaedic Surgery, Japan Red Cross Medical Center
  • MATSUI TATSUYA
    Department of Orthopaedic Surgery, Japan Red Cross Medical Center
  • HASUE MITSUO
    Department of Orthopaedic Surgery, Japan Red Cross Medical Center

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Other Title
  • Cefotiamの骨髄血, 骨組織への移行の検討
  • Cefotiam ノ コツズイケツ ホネ ソシキ エ ノ イコウ ノ ケントウ

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Abstract

The preoparative administration of cefotiam (CTM) 1 g by intravenous drip infusion for 30 minutes was performed. And the concentration of CTM in peripheral blood, bone marrow fluid and bone tissue was investigated. CTM was smoothly transmigrated from blood to bone tissue, and kept on the concentration in bone tissue over MIC values for several hours. These preliminary results encourage us to think that CTM may be as useful in prophylaxis against postoperative infections.

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