ULTRASTRUCTURAL CHANGES IN DIPHYLLOBOTHRIUM LATUM FROM MAN TREATED WITH PAROMOMYCIN SULFATE

  • TONGU YASUMASA
    Department of Parasitology, Okayama University, Medical School, Okayama, Japan
  • AJI TOSHIKI
    Department of Parasitology, Okayama University, Medical School, Okayama, Japan
  • FUKUDA TOMIO
    Department of Parasitology, Okayama University, Medical School, Okayama, Japan
  • ITANO KAZUO
    Department of Parasitology, Okayama University, Medical School, Okayama, Japan
  • INATOMI SEIM
    Department of Parasitology, Okayama University, Medical School, Okayama, Japan

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Other Title
  • 硫酸パロモマイシンで駆出した広節裂頭条虫体表の微細形態学的変化
  • リュウサン パロモマイシン デ カケダシタ コウセツレットウジョウチュウ タイ

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Abstract

The effect of paromomycin sulfate on Diphyllobothrium latum in vivo in man was examined morphologically with a scanning and a transmission electron microscope. The worm used for this study was expelled from a man by treatment with paromomycin sulfate at 1 dose of 50 mg/kg. The surface of the neck region suffered great damage. The effect of paromomycin sulfate resulted in the progressive breakup of the microtriches and thetegument. Even the basal lamina was lost in some parts. As a result, the muscle layers wereexposed directly to the air.In the immature proglottid, the basal lamina remained as an outermost surface, although paromomycin sulfate caused a great loss of the tegument. The mature proglottid was lacking microtriches in some parts. However, most of the tegument was covered with microtriches. The gravid proglottid remained without any loss of microtriches.

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