CLINICAL STUDIES ON PC-904 IN BILIARY TRACT DISEASES

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  • 胆道疾患におけるPC-904の臨床的検討
  • タンドウ シッカン ニ オケル PC-904 ノ リンショウテキ ケントウ

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Abstract

The clinical effects of PC-904, a new semisynthetic penicillin, were studied in patients with biliary tract diseases, and the results were as follows:<BR>1) PC-904 showed an average peak serum level of 40.7±11.6μg/ml 2 hours after an intravenous drip infusion of 1g of the agent. The biliary level showed a peak value of 126.5±85.4μg/ml 2 hours to 3 hours after the infusion.<BR>2) Isolated organisms from bile before the treatment were E. coli, Klebsiella, Proteus, Pseudomonas, Enterococcus and Bacteroides. MIC of PC-904 on 18 strains of isolated organisms was almost 6.25μg/ml or less. All isolated organisms except one strain of Klebsiella oxytoca disappeared after the treatment.<BR>3) Six patients with cholelithiasis were medicated with PC-904 to prevent post-operative infections. The clinical effects were good in 4, poor in 1 and unknown in 1 case.<BR>4) As to side effects no adverse reactions and allergic reactions were noted. Also no significant abnormalities of laboratory findings were observed.

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