CLINICAL STUDY WITH PIPERACILLIN IN THE FIELD OF OBSTETRICS AND GYNECOLOGY

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  • IKEDA MASANORI
    Department of Obstetrics and Gynecology, Kinki University, School of Medicine
  • NODA KIICHIRO
    Department of Obstetrics and Gynecology, Kinki University, School of Medicine

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  • 産婦人科領域におけるPiperacillinの使用経験
  • サンフジンカ リョウイキ ニ オケル Piperacillin ノ シヨウ ケ

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Abstract

1.Tissue concentrations of piperacillin (PIPC) between 80 to 150 minutes after the completion of 2g/1 hour dripping infusion were 4.6-6.4μg/g in the uterus, ovary and oviduct.These concentrations were higher than 80% MIC of the causative organisms, including Staphylococcus aureus, Escherichia coli, Proteus mirabilis, Bacteroides and Peptococcus, isolated from infections in the field of obstetrics and gynecology.<BR>2.The PIPC concentration in the retroperitoneal space exudate reached a peak value of 34.7μg/ml at 2 hours after the completion of 2g/l hour dripping infusion and thereafter maintained a constant level.These concentrations were sufficient for the therapy of parametritis.<BR>3. We administered PIPC at 4g per day for a period of 4-8 days to 4 patients with obstetrical and gynecological infectious diseases.All cases proved to respond effectively.No adverse effects and abnormal laboratory findings were observed.<BR>From the above, we considered that PIPC was an effective and safe antibiotic against infections in the field of obstetrics and gynecology.

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