EXCRETION IN BILE AND CLINICAL STUDY OF T-1220 (PIPERACILLIN) IN BILIARY TRACT DISEASES

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  • T-1220 (Piperacillin) の胆汁内排泄および胆道感染症に対する臨床的使用経験
  • T-1220(Piperacillin)の胆汁排泄および胆道感染症に対する臨床的使用経験
  • T-1220 Piperacillin ノ タンジュウ ハイセツ オヨビ タン

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Abstract

The excretion of T-1220 in bile was evaluated in 4 patients with biliary tract diseases. The bile was collected for 6 hours after intravenous injection of T-1220. The maximal concentration in bile was 1,600mcg/ml at 0.5-1 hour after administration of 1g of T-1220 to 1 case. In 3 cases treated with 2g, the maximal concentration was 155-1,115mcg/ml at 2-3 hours after administration. Total excretion rates in bile after 0-6 hours were 0.5-7.2%.<BR>T-1220 was applied clinically to 3 patients with biliary tract infections. Clinical results obtained were good in all cases.<BR>No side effect was observed in all cases.

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