COMPARATIVE STUDIES ON ACTIVITIES OF ANTIMICROBIAL AGENTS AGAINST CAUSATIVE ORGANISMS ISOLATED FROM URINARY TRACT INFECTIONS (1988)

KOSAKAI NOZOMU, KUMAMOTO YOSHIAKI, HIROSE TAKAOKI, TANAKA NORIAKI, HIKICHI YOSHINAO, SHIGETA SHIRO, SHIRAIWA YASUO, KAMEOKA HIROSHI, YOSHIDA HIROSHI, OGATA MASAHIRO, TAZAKI HIROSHI, IRI HISAMI, UCHIDA HIROSHI, KOBAYASHI YOSHIO, MATSUDA SEIJI, KITAGAWA RYUICHI, FUJITA KAZUHIKO, HAYASHI YASUYUK, OGURI TOYOKO, FURUSAWA TARO, TAKEUCHI YASUKO, MORIYAMA HIROMI, SHIBATA KIKUTARO, YONEZU SEIBUN, TAKAHA MINATO, MATSUMIYA KIYOMI, TANAKA MICHIO, YAMAGUCHI KEIZO, SUGAWARA KAZUYUKI, MOCHIDA CHIKAKO, HIRAKATA YOUICHI, IGARI JUN

doi:10.11553/antibiotics1968b.45.1071

Isolation frequencies and sensitivities to antibacterial and antibiotic agents were investigated on 801 bacterial strains isolated from patients with urinary tract infections in 9 hospitals during the period of June to November 1988. Of the above total bacterial population, Gram-positive bacteria accounted for 29.3% and a majority of them were Enterococcus spp. Gram-negative bacteria accounted for 70.7% and most of them were Escherichia coli. 1. Enterococcus faecalis Vancomycin was most active with its MIC₉₀≤0.78μg/ml. Ampicillin, piperacillin, ofloxacin (OFLX), ciprofloxacin (CPFX) and imipenem (IPM) were also active. 2. Staphylococcus aureus Arbekacin and minocycline were most active with their MIC₉₀s 0.39μg/ml and 1.56μg/ml, respectively. Among penicillins, dicloxacillin was the most active. Activities of cephems were considerably lower. 3. E. coli Most of the agents were tested active. Particularly the second and third generation cephems were active in a range of≤0.10-0.20μg/ml. Carumonam (CRMN), IPM, OFLX and CPFX were also active with MIC90s≤0.10μg/ml 4. Klebsiella pneumoniae CRMN and IPM were highly active. Penicillins generally showed lower activities. Cephems and new quinolones had high activities with their MIC9os in a range of 0.39-0.78μg/ml. 5. Proteus mirabilis The third generation cephems were active with their MIC₉₀s in a range of≤0.10-0.20μg/ml. CRMN, OFLX and CPFX were also active with their MIC90s≤0.10μg/ml, 0.39μg/ml and 0.20g/ml, respectively. 6. Pseudomonas aeruginosa IPM and tobramycin were active with their MIC90s 1.56μg/ml and 3.13μg/ml, respectively. CRMN and new quinolones showed MIC₈₀s of 25-100μg/ml. Most of penicillins and cephems were not active. 7. Other Gram-negative rods Against Citrobacter freundii, Enterobacter cloacae and Serratia marcescens, IPM, CPFX and OFLX were active. Penicillins and cephems were not so active. CRMN was active against S. marcescens with its MICK, at 6.25μg/ml.8

COMPARATIVE STUDIES ON ACTIVITIES OF ANTIMICROBIAL AGENTS AGAINST CAUSATIVE ORGANISMS ISOLATED FROM URINARY TRACT INFECTIONS (1988)

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