SENSITIVITY SURVEILLANCE OF <I>Streptococcus pneumoniae</I>ISOLATES FOR SEVERAL ANTIBIOTICS IN GIFU PREFECTURE (2004)

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  • MITSUYAMA JUNICHI
    Working Group of Tokai Anti-biogram study group Research Laboratories of Toyama Chemical Co., Ltd.
  • YAMAOKA KAZUKIYO
    Working Group of Tokai Anti-biogram study group Gifu College of Medical Technology
  • ASANO YUKO
    Working Group of Tokai Anti-biogram study group Department of Clinical Laboratory Medicine, Ogaki Municipal Hospital
  • SAWAMURA HARUKI
    Working Group of Tokai Anti-biogram study group Gifu University School of Medicine
  • SUEMATSU HIROYUKI
    Working Group of Tokai Anti-biogram study group Clinical Laboratories, Chuno General Hospital
  • TERACHI MAYUMI
    Working Group of Tokai Anti-biogram study group Hida Clinical Research Center
  • HASHIDO HIKONORI
    Working Group of Tokai Anti-biogram study group Takayama Red Cross Hospital
  • MATSUKAWA YOKO
    Working Group of Tokai Anti-biogram study group Clinical Laboratories, Gifu Prefectual Tajimi Hospital
  • MATSUBARA SHIGENORI
    Working Group of Tokai Anti-biogram study group Matsubara Otorhinolaryngology Clinic
  • MIYABE TAKANORI
    Working Group of Tokai Anti-biogram study group Clinical Laboratories, Tokai Central Hospital
  • MIKAMO HIROSHIGE
    Working Group of Tokai Anti-biogram study group Division of Anaerobe Research, Life Science Research Center, Gifu University
  • WATANABE KUNITOMO
    Working Group of Tokai Anti-biogram study group Division of Anaerobe Research, Life Science Research Center, Gifu University

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  • 岐阜県下における肺炎球菌の各種抗菌薬に対する感受性サーベイランス-2004年
  • ギフ ケンカ ニ オケル ハイエン キュウキン ノ カクシュ コウキンヤク ニ タイスル カンジュセイ サーベイランス 2004ネン

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We analyzed Streptococcus pneumoniae isolates in Gifu prefecture between November 2004 and December 2004. We analyzed isolates of 160 strains from 8 medical facilities to determine antibiotic susceptibility, genotype of penicillin-binding protein (PBP) genes and macrolide resistant genes, and the serotypes of penicillinresistantS. pneumoniae (PRSP).<BR>When referred to the classification in CLSI (formerly NCCLS), the overall incidence of penicillin-susceptible (PSSP), penicillin-intermediate (PISP) and penicillin-resistant (PRSP) were 48 (30.0%), 81 (50.6%) and 31 (19.4%) strains, respectively, and the susceptibility distribution to benzylpenicillin showed triplet peaks.<BR>The incidence of PISP and PRSP was higher in the material of throat and nasal cavity, and area of Chuno and Gifu district. The sum of the incidence of PISP and PRSP was slightly higher in inpatient-derived stains than outpatient-derived strains.<BR>The incidence that didn't possess mutations in PBP genes and macrolide-resistant genes was 6 (3.75%) and the others 154 strain (96.25%) had abnormal PBP genes or macrolide-resistant genes. The 90% of pneumococcal serotypes of PRSP 31 strains were serotype 6 (14 strains, 45.2%), 19 (7 strains, 22.6%) and 23 (7 strains, 22.6%).<BR>The MIC90 of each antibiotics was as follows; 0.1μg/mL for panipenem, 0.2μg/mL for imipenem and tosufloxacin, 0.39μg/mL for meropenem and gatifloxacin, 0.78μg/mL for amoxicillin, cefteram and cefditoren, 1.56μg/mL for piperacillin, cefcapene and levofloxacin, 3.13μg/mL for flomoxef, 6.25μg/mL for cefdinir and cefotiam, 12.5μg/mL for norfloxacin and minocycline, 25μg/mL for cefixime, and 100μg/mL for clarithromycin.

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