PENETRATION OF LEVOFLOXACIN IN BILE

  • MIZUNO AKIRA
    Department of Surgery, Takahama Municipal Hospital
  • SUZUKI TATSUYA
    Department of Surgery, Takahama Municipal Hospital
  • TANIGUCHI MASAAKI
    Department of Surgery, Takahama Municipal Hospital
  • YURA JIRO
    The First Department of Surgery, Medical School, Nagoya City University
  • SHINAGAWA NAGAO
    The First Department of Surgery, Medical School, Nagoya City University
  • ISHIKAWA SHU
    The First Department of Surgery, Medical School, Nagoya City University
  • MASHITA KEIJI
    The First Department of Surgery, Medical School, Nagoya City University
  • SUZUI KATSUYA
    The First Department of Surgery, Medical School, Nagoya City University
  • ISHIKAWA MASAKAZU
    The First Department of Surgery, Medical School, Nagoya City University
  • ISHIHARA HIROSHI
    The First Department of Surgery, Medical School, Nagoya City University

Bibliographic Information

Other Title
  • Levofloxacin の胆汁中移行

Abstract

he penetration into bile of a new pyridonecarboxylic acid derivative, levofloxacin (LVFX), was studied in a closs-over method with ofloxacin (OFLX) as the control drug in 6 post-operative patients. The lengths of time to the maximum concentrations in bile and the total areas under the curves were both almost the same for these 2 compounds, although the maximum bile concentration of LVFX was slightly lower than that of OFLX. A stability test for LVFX in human bile revealed that over 95.4% of the initial amount was recovered up to 24 hours after commencement of incubation at a room temperature, thus the stability in bile was similar to that in water. The penetration of LVFX which possesses twice as strong antibacterial activities as OFLX was similar to that of OFLX, suggesting that LVFX is useful against bile duct infections.

Journal

Details 詳細情報について

  • CRID
    1390001205494914560
  • NII Article ID
    130004395333
  • DOI
    10.11553/antibiotics1968b.45.569
  • COI
    1:CAS:528:DyaK38Xls1egs74%3D
  • ISSN
    21865477
    03682781
  • PubMed
    1512943
  • Text Lang
    ja
  • Data Source
    • JaLC
    • PubMed
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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