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- MIZUNO AKIRA
- Department of Surgery, Takahama Municipal Hospital
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- SUZUKI TATSUYA
- Department of Surgery, Takahama Municipal Hospital
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- TANIGUCHI MASAAKI
- Department of Surgery, Takahama Municipal Hospital
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- YURA JIRO
- The First Department of Surgery, Medical School, Nagoya City University
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- SHINAGAWA NAGAO
- The First Department of Surgery, Medical School, Nagoya City University
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- ISHIKAWA SHU
- The First Department of Surgery, Medical School, Nagoya City University
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- MASHITA KEIJI
- The First Department of Surgery, Medical School, Nagoya City University
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- SUZUI KATSUYA
- The First Department of Surgery, Medical School, Nagoya City University
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- ISHIKAWA MASAKAZU
- The First Department of Surgery, Medical School, Nagoya City University
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- ISHIHARA HIROSHI
- The First Department of Surgery, Medical School, Nagoya City University
Bibliographic Information
- Other Title
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- Levofloxacin の胆汁中移行
Abstract
he penetration into bile of a new pyridonecarboxylic acid derivative, levofloxacin (LVFX), was studied in a closs-over method with ofloxacin (OFLX) as the control drug in 6 post-operative patients. The lengths of time to the maximum concentrations in bile and the total areas under the curves were both almost the same for these 2 compounds, although the maximum bile concentration of LVFX was slightly lower than that of OFLX. A stability test for LVFX in human bile revealed that over 95.4% of the initial amount was recovered up to 24 hours after commencement of incubation at a room temperature, thus the stability in bile was similar to that in water. The penetration of LVFX which possesses twice as strong antibacterial activities as OFLX was similar to that of OFLX, suggesting that LVFX is useful against bile duct infections.
Journal
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- The Japanese Journal of Antibiotics
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The Japanese Journal of Antibiotics 45 (5), 569-575, 1992
Japan Antibiotics Research Association