A STUDY ON THE PENETRATION OF CEFMENOXIME INTO BILE AND GALLBLADDER TISSUES AND PATHOLOGICAL CHANGES OF INFLAMED TISSUES

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  • Cefmenoximeの胆汁中及び胆嚢炎症病巣への移行に関する検討

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Abstract

The penetration of cefmenoxime (CMX) into bile and gallbladder tissues was studied. A dose of 2g CMX was given intravenously to each of patients with gallstones.<BR>Concentrations of CMX in the gallbladder tissues were 120.6±39.8μg/g in normal tissues about 2 hours after the administration and 128.3±52.3μg/g in inflamed tissues.<BR>The penetration of CMX into gallbladder tissue tended to decrease in proportion to the severity of inflammation, but the difference between the 2 groups, normal and inflamed tissues, were not satistically significant.<BR>The penetration of CMX into gallbladder tissue was presumed to increase in proportion to increase in the serum concentration of CMX.<BR>The result indicated that the achievement of high concentrations of CMX in the serum is important in the treatment of bilialy tract diseases.

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