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- YURA JIRO
- The 1st Department of Surgery, Nagoya City University Medical School
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- TSURUGA NOBUATSU
- The 1st Department of Surgery, Nagoya City University Medical School
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- HASHIMOTO TAKASHI
- The 1st Department of Surgery, Nagoya City University Medical School
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- KAMIYA YASUHIRO
- The 1st Department of Surgery, Nagoya City University Medical School
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- HAYASHI SHUSAKU
- The 1st Department of Surgery, Nagoya City University Medical School
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- MURATA YUKITAKA
- The 1st Department of Surgery, Nagoya City University Medical School
Bibliographic Information
- Other Title
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- 小児外科領域におけるCefotiamの基礎的, 臨床的評価
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Abstract
Pharmacokinetics and clinical studies on cefotiam (CTM) in pediatric surgery were performed and the results obtained are summarized below.<BR>1. In neonates without congenital heart disease (CHD), serum levels of CTM were rapidly increased following injection of CTM (20mg/kg, one shot intravenous administration) and the peak values were found at 15 minutes. Six hours later, CTM almost disappeared from the blood. In:the patient with CHD, however, CTM was retained in the serum and the urinary excretion was poor.<BR>2. The CTM was administrated prophylactically to prevent postoperative infections in 10 patients. Eight of 10 had no episodes during postoperative period. Wound infection, however, was found in 2 patients. No clinical and laboratory side effects were caused by CTM.
Journal
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- The Japanese Journal of Antibiotics
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The Japanese Journal of Antibiotics 39 (9), 2483-2487, 1986
Japan Antibiotics Research Association