PHARMACOKINETICS AND CLINICAL STUDIES ON AZTREONAM IN NEONATES AND PREMATURE INFANTS (THE FIRST REPORT)
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- FUJII RYOCHI
- Department of Pediatrics, School of Medicine, Teikyo University Institute of Chemotherapy for Mother and Child
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- HASHIRA SHINTARO
- Department of Pediatrics, Asahikawa Medical College
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- TAJIMA TAKESHI
- Department of Pediatrics, Asahikawa Medical College
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- MEGURO HIDENORI
- Department of Pediatrics, Asahikawa Medical College
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- ABE TOSHIAKI
- Department of Pediatrics, Asahikawa Medical College
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- SAKATA HIROSHI
- Department of Pediatrics, Asahikawa Kosei Hospital
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- KAKEHASHI HITOSHI
- Department of Pediatrics, Asahikawa Kosei Hospital
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- FUJITA KOZO
- Department of Pediatrics, Asahikawa Kosei Hospital
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- MURONO KO-ICHI
- Department of Pediatrics, Asahikawa Kosei Hospital
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- KAERIYAMA MASATO
- Department of Pediatrics, Asahikawa Kosei Hospital
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- OKA TOSHIAKI
- Department of Pediatrics, Asahikawa Kosei Hospital
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- YOSHIOKA HAJIME
- Department of Pediatrics, Asahikawa Kosei Hospital
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- HIRAMOTO AZUMA
- Department of Pediatrics, Furano Kyokai Hospital
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- MORI YOSHIKI
- Department of Pediatrics, Furano Kyokai Hospital
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- MARUYAMA SHIZUO
- Department of Pediatrics, Furano Kyokai Hospital
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- INYAKU FUMIE
- Department of Pediatrics, School of Medicine, Keio University
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- AZAGAMI SHIRO
- Department of Pediatrics, Tokyo Metropolitan Kiyose Children's Hospital
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- ISOHATA EIICHI
- Department of Pediatrics, Tokyo Metropolitan Kiyose Children's Hospital
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- OIKAWA TADAO
- Department of Pediatrics, Tokyo Metropolitan Kiyose Children's Hospital
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- OSANO MITSURU
- Department of Pediatrics, Tokyo Metropolitan Kiyose Children's Hospital
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- SHIRO HIROYUKI
- Department of Pediatrics, The Second Tokyo National Hospital
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- SUNAKAWA KEISUKE
- Department of Pediatrics, Kasumigaura National Hospital
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- ISHIZUKA YUGO
- Department of Pediatrics, Kasumigaura National Hospital
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- SAITO NOBUO
- Department of Pediatrics, Kasumigaura National Hospital
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- IWATA SATOSHI
- Department of Pediatrics, School of Medicine, Showa University
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- NAKAZAWA SUSUMU
- Department of Pediatrics, The Tokyo Metropolitan Ebara General Hospital
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- SATO HAJIME
- Department of Pediatrics, Ohguchi Higashi General Hospital
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- NARITA AKIRA
- Department of Pediatrics, Ohguchi Higashi General Hospital
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- SUZUKI HIROYUKI
- Department of Pediatrics, Ohguchi Higashi General Hospital
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- NAKAZAWA SHIN-ICHI
- Department of Pediatrics, Ohguchi Higashi General Hospital
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- MATSUMOTO KIMIKO
- Department of Pediatrics, Ohguchi Higashi General Hospital
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- NAKANISHI YOSHIKO
- Department of Pediatrics, Ohguchi Higashi General Hospital
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- NIINO KENJI
- Department of Pediatrics, The Jikei University School of Medicine
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- TOYONAGA YOSHIKIYO
- Department of Pediatrics, Fuji Municipal Central Hospital
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- SUGITA MORIMASA
- Department of Pediatrics, Fuji Municipal Central Hospital
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- NAKAMURA HIRONORI
- Department of Pediatrics, Fuji Municipal Central Hospital
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- KAWAMURA KEN-ICHI
- Department of Pediatrics, School of Medicine, Mie University
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- SEO KIWAMU
- Department of Pediatrics, School of Medicine, Mie University
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- ARAI SHOJIRO
- Department of Pediatrics, Yamada Red Cross Hospital
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- KAMIYA HITOSHI
- Department of Pediatrics, Yamada Red Cross Hospital
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- SAKURAI MINORU
- Department of Pediatrics, Yamada Red Cross Hospital
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- SUZUKI MASAHARU
- Department of Pediatrics, National Tsu Hospital
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- KOJIMA MASAMITSU
- Department of Pediatrics, National Tsu Hospital
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- NOMURA TOYOKI
- Department of Pediatrics, Meitetsu Hospital
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- INAMOCHI HIDEKI
- Department of Pediatrics, Meitetsu Hospital
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- IWAI NAOICHI
- Department of Pediatrics, Chita Municipal Hospital
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- NAKAMURA HARUHI
- Department of Pediatrics, Chita Municipal Hospital
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- TANEDA YOH-ICHI
- Department of Pediatrics, Meijo Hospital
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- MAKI TAKAKO
- Department of Pediatrics, Showa Hospital
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- OZAKI TAKAO
- Department of Pediatrics, Ohgaki Municipal Hospital
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- MATSUI SHOJI
- Department of Pediatrics, Ohgaki Municipal Hospital
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- TAUCHI NOBUO
- Department of Pediatrics, Osaka Medical College
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- ICHIKAWA TAKAYUKI
- Department of Pediatrics, Osaka Medical College
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- NISHIMURA TADAFUMI
- Department of Pediatrics, Kobe Central Municipal Hospital
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- TABUKI KAZUO
- Department of Pediatrics, Kobe Central Municipal Hospital
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- OHKURA KAN-ETSU
- Kobe City College of Nursing
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- MATSUDA TADASHI
- Kobe City College of Nursing
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- NIGAMI HIROYUKI
- Kobe City College of Nursing
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- YAMAKAWA MASARU
- Kobe City College of Nursing
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- KUROKI SHIGEKAZU
- Kobe City College of Nursing
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- HARUTA TSUNEKAZU
- Kobe City College of Nursing
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- KOBAYASHI YUTAKA
- Department of Pediatrics, School of Medicine, Kurume University
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- MOTOHIRO TAKASHI
- Department of Pediatrics, School of Medicine, Kurume University
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- KOGA TATSUHIKO
- Department of Pediatrics, School of Medicine, Kurume University
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- SAKATA YASUTAKA
- Department of Pediatrics, School of Medicine, Kurume University
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- ISHIMOTO KOHJI
- Department of Pediatrics, School of Medicine, Kurume University
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- YAMASHITA FUMIO
- Department of Pediatrics, School of Medicine, Kurume University
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- TANAKA HIROYA
- Department of Pediatrics, School of Medicine, Nagasaki University
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- FUKUDA MASAFUMI
- Department of Pediatrics, School of Medicine, Nagasaki University
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- INOGUCHI SHUNJI
- Department of Pediatrics, School of Medicine, Nagasaki University
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- TSUJI YOSHIRO
- Department of Pediatrics, School of Medicine, Nagasaki University
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- SHIMOMURA HIROSHI
- Department of Pediatrics, School of Medicine, Juntendo University
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- MIYANO TAKESHI
- Department of Pediatrics, School of Medicine, Juntendo University
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- KIMURA KOH-ICHIRO
- Department of Pediatrics, School of Medicine, Juntendo University
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- YURA JIRO
- The First Department of Surgery, Nagoya City University, Medical School
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- SUZUKI TATSUYA
- The First Department of Surgery, Nagoya City University, Medical School
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- HASHIMOTO TAKASHI
- The First Department of Surgery, Nagoya City University, Medical School
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- NAKAMURA TSUKASA
- The First Department of Surgery, Nagoya City University, Medical School
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- SHIMIZU YASUNOBU
- The First Department of Surgery, Nagoya City University, Medical School
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- MINAMI MUNEHITO
- The First Department of Surgery, Nagoya City University, Medical School
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- KAMIYA YASUHIRO
- The First Department of Surgery, Nagoya City University, Medical School
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- NARITA HIROSHI
- The First Department of Surgery, Nagoya City University, Medical School
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- TSURUGA NOBUATSU
- The First Department of Surgery, Nagoya City University, Medical School
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- YAGISAWA MORIMASA
- Japan Antibiotics Research Association
Bibliographic Information
- Other Title
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- 新生児, 未熟児におけるAztreonamの薬動力学的並びに臨床的検討
- STUDY ON EFFECTIVENESS AND SAFETY IN MONO-THERAPY WITH AZTREONAM
- 第1報Aztreonam単独投与による有効性及び安全性の検討
Abstract
Pharmacokinetics and clinical study of aztreonam (AZT) in neonates and premature infants were conducted with the following results:<BR>1. Pharmacokinetics<BR>(1) Serum concentrations of AZT at 30 minutes after one-shot intravenous injection of 10 mg/kg and 20 mg/kg to neonates including premature infants were 20.6-26.6μg/ml and 38.5-46.4μg/ml, respectively, and decreased thereafter. A dose response was observed in the serum concentrations with administration of AZT 10 mg/kg and 20 mg/kg.<BR>(2) Serum half-lives (T 1/2) tended to be shorter in both mature and premature infants as their day-ages increased and T 1/2 tended to be prolonged in premature infants compared with mature infants.<BR>(3) Changes in serum concentration upon one-hour intravenous drip infusion of AZT 20 mg/kg were very similar to those upon one-shot intravenous injection.<BR>(4) Urinary excretions in the first 6 hours after one-shot intravenous injection of AZT 10mg/kg or 20 mg/kg tended to increase in mature infants as they grew and showed excretion rate of 26.2-54.3% but those in premature infants did not show any specific tendency with rate of 17.5-45.1%. Urinary excretions upon intravenous drip-infusion showed a tendency very similar to those upon intravenous injection.<BR>2. Clinical studies<BR>(1) Clinically evaluable cases of AZT treatment were 88 cases (91 diseases), in which pathogenic organisms were identified in 56 cases (Group A), i.e., sepsis 9, purulent meningitis 2, pneumonia 8, urinary tract infection (UTI) 33 and others. Total efficacy rate was 98.2% including “excellent” (39), “good”(16) and “fair”(1). Number of cases in which pathogenic organisms were unknown (Group B) was 11, i.e., suspected sepsis (4), pneumonia (3) and intrauterine infection (4) and the efficacy rate was 100% with “excellent”(4) and “good” (7). Thus, both group A and B showed excellent results. AZT was also given to 24 cases for prophylaxis and all the cases showed prophylactic effect of AZT.<BR>(2) Bacteriologically AZT was deemed effective in 53 cases out of 56 (Group A) with identified pathogens “eradicated”(51) and “unchanged”(2), thus the bacterial eradication rate was 96.2%.<BR>(3) A minor degree of loose feces was observed in 1 (1.3%) of 80 cases as a side effect. Abnormal laboratory test values found were eosinophilia (3 cases), elevation of GOT and GPT (2), platelet-increase (1), elevation of GOT (1), and thrombocytopenia·elevation of GOT·GPT·LDH (1). Every one of these was of a minor degree and transient.<BR>From the above pharmacokinetics and clinical results, standard dosage of AZT to neonates and premature infants should be in a unit dose of 20 mg/kg, twice daily to those with ages between 0 and 3 days, and 2 to 3 times daily to those with ages 4 days and above, by intravenous injection or intravenous drip infusion.
Journal
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- The Japanese Journal of Antibiotics
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The Japanese Journal of Antibiotics 43 (3), 543-562, 1990
Japan Antibiotics Research Association