CLINICAL TRIAL OF FORPHENICINOL FOR THE LUNG INFECTION WITH <I>MYCOBACTERIUM AVIUM</I>, <I>MYCOBACTERIUM INTRACELLULARE</I> COMPLEX

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  • <I>Mycobacterium avium</I>, <I>Mycobacterium intracellulare complex</I> 肺感染症に対するForphenicinol の臨床的検討

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Abstract

Clinical evaluation of forphenicinol, a low molecular weight immunomodulator, in patients with Mycobacterium avium, Mycobacterium intracellulare complex pulmonary infections has been conducted in a multicenter trial participated by 9 institutions in Kyushu during a period of 12 months from July 1982 to August 1983. Forphenicinol was administered for 6 months without changing the regimen of antituberculous drugs used previously. The following results were obtained.<BR>1. Ten out of 33 eligible patients were evaluated as showing good responses; In 5 of them, elimination of M. avium, M. intracellulare complex from sputum was observed. In the other 5 patients, number of bacilli excreted was decreased significantly after treatment.<BR>2. All of the cases with good responses were those which were simultaneously administered with antituberculous drugs.<BR>3. Patients with thick-walled cavities, following cured tuberculosis, which was superimposed with M. avium, M. intracellulare complex, were poorly responded to forphenicinol.<BR>4. Side effects were observed in 3 out of 41 patients; 1 case each with fever, abdominal distension and anorexia. No abnormalities in laboratory test values were observed.

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