Double-Blind Trial of Amikacin (BB-K8)in the Treatment of Acute Supprative Otitis Media and Acute Tonsillitis

DOI
  • BABA Shunkichi
    Department of Otorhinolaryngology, Nagoya City University School of Medicine
  • SANBE Buemon
    Department of Otorhinolaryngology, Kanto Teishin Hospital
  • MURAKAMI Haruko
    Department of Otorhinolaryngology, Kanto Teishin Hospital
  • UEDA Ryoho
    Department of Otorhinolaryngology, Kanto Teishin Hospital
  • SATO Kiichi
    Department of Pathology, Medical Research Institute, Tokyo Medical and Dental University
  • AWATAGUCHI Shogo
    Department of Otorhinolaryngology, Hirosaki University School of Medicine
  • HIRAOKA Mariko
    Department of Otorhinolaryngology, Hirosaki University School of Medicine
  • KAMADA Shigeru
    Department of Otorhinolaryngology, Hirosaki University School of Medicine
  • KAWABATA Takehiro
    Department of Otorhinolaryngology, Hirosaki University School of Medicine
  • KAWAMURA Shozo
    Department of Otorhinolaryngology, Juntendo University School of Medicine
  • ICHIKAWA Ginichiro
    Department of Otorhinolaryngology, Juntendo University School of Medicine
  • SUGITA Rinya
    Department of Otorhinolaryngology, Juntendo University School of Medicine
  • HOSUI Masafumi
    Department of Otorhinolaryngology, Tokyo Teishin Hospital, Tokyo, Japan
  • OSAWA Hiroyuki
    Department of Otorhinolaryngology, Tokyo Teishin Hospital, Tokyo, Japan
  • SAITO Yozo
    Department of Otorhinolaryngology, Tokyo Medical and Dental University
  • OGAWA Akira
    Department of Otorhinolaryngology, Tokyo Medical and Dental University
  • SHIBUI Koichi
    Department of Otorhinolaryngology, Asoka Hospital
  • NANJO Shoichi
    Department of Otorhinolaryngology, Kanto Chuo Hospital
  • TAKAFUJI Tsuguo
    Department of Otorhinolaryngology, Tokyo Kosei Nenkin Hospital
  • NAKANO Michii
    Department of Otorhinolaryngology, Tokyo Kosei Nenkin Hospital
  • OGURA Shuji
    Department of Otorhinolaryngology, Japan Red Cross Medical Center
  • MASUKO Saburo
    Department of Otorhinolaryngology, Japan Red Cross Medical Center
  • TAKASU Teruo
    Department of Otorhinolaryngology, Fujitagakuen University School of Medicine
  • IWATA Shigenobu
    Department of Otorhinolaryngology, Fujitagakuen University School of Medicine
  • SEKIYA Tadao
    Department of Otorhinolaryngology, Nagoya National Hospital, Nagoya, Japan
  • OTSUKA Motoi
    Department of Otorhinolaryngology, Nagoya National Hospital, Nagoya, Japan
  • YAMAMOTO Kaoru
    Department of Otorhinolaryngology, Osaka City University School of Medicine
  • SUGIYAMA Masao
    Department of Otorhinolaryngology, Osaka City University School of Medicine
  • YAMAMOTO Masahiro
    Department of Otorhinolaryngology, Osaka City University School of Medicine
  • TAKEDA Kazuo
    Department of Otorhinolaryngology, Osaka Medical College
  • NAKAMURA Fumiaki
    Department of Otorhinolaryngology, Osaka Medical College
  • ISHII Hironori
    Department of Otorhinolaryngology, Osaka Medical College
  • HIROTO Ikuichiro
    Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University
  • WATANABE Susumu
    Department of Otorhinolaryngology, Kyushu Kosei Nenkin Hospital
  • MURATA Yoshiharu
    Department of Otorhinolaryngology, Kyushu Kosei Nenkin Hospital
  • SAKUMA Akira
    Department of Clinical Pharmacology, Medical Research Institute, Tokyo Medical and Dental University
  • KOSAKAI Nozomu
    Department of Clinical Pathology, Juntendo University School of Medicine
  • OGURI Toyoko
    Department of Clinical Pathology, Juntendo University School of Medicine

Bibliographic Information

Other Title
  • 急性化膿性中耳炎ならびに急性扁桃炎に対するAmikacin (BB-K8) の薬効評価
  • -Aminodeoxykanamycinとの二重盲検試験による検討-

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Abstract

To evaluate objectively the effect of amikacin (BB-K8) on acute supprative otitis media and acute tonsillitis, a double-blind trial was carried out using aminodeoxykanamycin (AKM) as a control drug.<BR>Effectiveness rate by total judgement on each disease in adult and primary school patients was 54.6% in BB-K8 and 70.0% in AKM in adult patients with acute supprative otitis media, and 83.3% in BB-K8 and 61.7% in AKM in primary school patients with supprative otitis media. Also it was 76.6% in BB-K8 and 75.5% in AKM in adult patients with acute tonsillitis, and 94.1% in BB-K8 and 88.2% in AKM in primary school patients with acute tonsillitis.<BR>Statistical superiority of BB-K8 to AKM was noted in primary school patients with acute supprative otitis media (P<0.1).<BR>In adult patients with acute supprative otitis media relatively higher effectiveness rate was seemingly obtained in AKM in comparison with BB-K8. Such results as obtained above and the assessments made in AKM so far may be concluded efficacy of BB-K8. As to the adverse reactions there observed no difference between both agents and no abnormality in hearing acuity was noted.

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