Double-Blind Trial of Amikacin (BB-K8)in the Treatment of Acute Supprative Otitis Media and Acute Tonsillitis
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- BABA Shunkichi
- Department of Otorhinolaryngology, Nagoya City University School of Medicine
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- SANBE Buemon
- Department of Otorhinolaryngology, Kanto Teishin Hospital
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- MURAKAMI Haruko
- Department of Otorhinolaryngology, Kanto Teishin Hospital
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- UEDA Ryoho
- Department of Otorhinolaryngology, Kanto Teishin Hospital
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- SATO Kiichi
- Department of Pathology, Medical Research Institute, Tokyo Medical and Dental University
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- AWATAGUCHI Shogo
- Department of Otorhinolaryngology, Hirosaki University School of Medicine
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- HIRAOKA Mariko
- Department of Otorhinolaryngology, Hirosaki University School of Medicine
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- KAMADA Shigeru
- Department of Otorhinolaryngology, Hirosaki University School of Medicine
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- KAWABATA Takehiro
- Department of Otorhinolaryngology, Hirosaki University School of Medicine
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- KAWAMURA Shozo
- Department of Otorhinolaryngology, Juntendo University School of Medicine
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- ICHIKAWA Ginichiro
- Department of Otorhinolaryngology, Juntendo University School of Medicine
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- SUGITA Rinya
- Department of Otorhinolaryngology, Juntendo University School of Medicine
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- HOSUI Masafumi
- Department of Otorhinolaryngology, Tokyo Teishin Hospital, Tokyo, Japan
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- OSAWA Hiroyuki
- Department of Otorhinolaryngology, Tokyo Teishin Hospital, Tokyo, Japan
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- SAITO Yozo
- Department of Otorhinolaryngology, Tokyo Medical and Dental University
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- OGAWA Akira
- Department of Otorhinolaryngology, Tokyo Medical and Dental University
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- SHIBUI Koichi
- Department of Otorhinolaryngology, Asoka Hospital
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- NANJO Shoichi
- Department of Otorhinolaryngology, Kanto Chuo Hospital
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- TAKAFUJI Tsuguo
- Department of Otorhinolaryngology, Tokyo Kosei Nenkin Hospital
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- NAKANO Michii
- Department of Otorhinolaryngology, Tokyo Kosei Nenkin Hospital
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- OGURA Shuji
- Department of Otorhinolaryngology, Japan Red Cross Medical Center
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- MASUKO Saburo
- Department of Otorhinolaryngology, Japan Red Cross Medical Center
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- TAKASU Teruo
- Department of Otorhinolaryngology, Fujitagakuen University School of Medicine
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- IWATA Shigenobu
- Department of Otorhinolaryngology, Fujitagakuen University School of Medicine
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- SEKIYA Tadao
- Department of Otorhinolaryngology, Nagoya National Hospital, Nagoya, Japan
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- OTSUKA Motoi
- Department of Otorhinolaryngology, Nagoya National Hospital, Nagoya, Japan
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- YAMAMOTO Kaoru
- Department of Otorhinolaryngology, Osaka City University School of Medicine
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- SUGIYAMA Masao
- Department of Otorhinolaryngology, Osaka City University School of Medicine
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- YAMAMOTO Masahiro
- Department of Otorhinolaryngology, Osaka City University School of Medicine
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- TAKEDA Kazuo
- Department of Otorhinolaryngology, Osaka Medical College
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- NAKAMURA Fumiaki
- Department of Otorhinolaryngology, Osaka Medical College
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- ISHII Hironori
- Department of Otorhinolaryngology, Osaka Medical College
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- HIROTO Ikuichiro
- Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University
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- WATANABE Susumu
- Department of Otorhinolaryngology, Kyushu Kosei Nenkin Hospital
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- MURATA Yoshiharu
- Department of Otorhinolaryngology, Kyushu Kosei Nenkin Hospital
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- SAKUMA Akira
- Department of Clinical Pharmacology, Medical Research Institute, Tokyo Medical and Dental University
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- KOSAKAI Nozomu
- Department of Clinical Pathology, Juntendo University School of Medicine
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- OGURI Toyoko
- Department of Clinical Pathology, Juntendo University School of Medicine
Bibliographic Information
- Other Title
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- 急性化膿性中耳炎ならびに急性扁桃炎に対するAmikacin (BB-K8) の薬効評価
- -Aminodeoxykanamycinとの二重盲検試験による検討-
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Abstract
To evaluate objectively the effect of amikacin (BB-K8) on acute supprative otitis media and acute tonsillitis, a double-blind trial was carried out using aminodeoxykanamycin (AKM) as a control drug.<BR>Effectiveness rate by total judgement on each disease in adult and primary school patients was 54.6% in BB-K8 and 70.0% in AKM in adult patients with acute supprative otitis media, and 83.3% in BB-K8 and 61.7% in AKM in primary school patients with supprative otitis media. Also it was 76.6% in BB-K8 and 75.5% in AKM in adult patients with acute tonsillitis, and 94.1% in BB-K8 and 88.2% in AKM in primary school patients with acute tonsillitis.<BR>Statistical superiority of BB-K8 to AKM was noted in primary school patients with acute supprative otitis media (P<0.1).<BR>In adult patients with acute supprative otitis media relatively higher effectiveness rate was seemingly obtained in AKM in comparison with BB-K8. Such results as obtained above and the assessments made in AKM so far may be concluded efficacy of BB-K8. As to the adverse reactions there observed no difference between both agents and no abnormality in hearing acuity was noted.
Journal
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- OTOLOGIA FUKUOKA
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OTOLOGIA FUKUOKA 22 (1), 51-76, 1976
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Details 詳細情報について
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- CRID
- 1390001205496338432
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- NII Article ID
- 130004132733
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- ISSN
- 04477227
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed