A COMPARATIVE STUDY ON THE CLINICAL UTILITY OF CEFOZOPRAN AND CEFPIROME AGAINST COMPLICATED URINARY TRACT INFECTIONS

KAMIDONO SADAO, ARAKAWA SOICHI, MATSUI TAKASHI, ITO NOBORU, SHINOZAKI MASASHI, TSUJI TAKUMI, MINAYOSHI KENJI, KAWABATA GAKU, MIZUNO YOSHIHITO, OKAMOTO YASUYUKI, UMEZU KEIICHI, TANAKA KAZUSHI, NAGATA HITOSHI, MARUYAMA SATOSHI, FUJII AKIRA, MATSUMOTO HIROTO, MATSUMOTO OSAMU, TANAKA HIROKAZU, OHBE SATOSHI, YAMASHITA MASUO, NAKAMURA ICHIRO, YOSIYUKI KAZUMA, MORISUE KOICHI, KONDO KANEYASU, IMANISHI OSAMU, HAZAMA MINORU, KA SHOJIN, KOMINAMI MASAKI

doi:10.11553/antibiotics1968b.53.430

Aiming at evaluating the utility of cefozopran (CZOP) against complicated urinary tract infections with the velocity of eradication of causal bacteria in early treatment and clinical efficacy by new criteria of UTIs, a comparative study was conducted using cefpirome (CPR) as the control drug. CZOP and CPR were administered by intravenous drip infusion at a dose of 1g twice daily. The duration of treatment was for 5 days. The study method involved randomized assignment of the subjects to either group CZOP or group CPR. The results were as follows: 1. Of a total of 80 cases treated, 65 (CZOP group-32 cases, CPR group-33 cases) were evaluated for efficacy. 2. The overall clinical efficacy evaluation according to the criteria proposed by Japanese UTI Committee rated the CZOP group as 90.6% (29/32), and the CPR group as 90.9% (30/33), with no significant difference between the 2groups. Clinical efficacy evaluated by attending physicians rated the CZOP group as 93.8% (30/ 32) and the CPR group as 90.9% (30/33). There was no significant difference between the 2 groups. 3. The efficacy rates to pyuria on day 2 were 26.7% and 0% for the CZOP group and the CPR group, respectively, indicating a higher efficacy rate for the former (p<0.05). Those on after treatment were 59.4% and 54.5% for the CZOP group and the CPR group, respectively, with no significant difference between the 2 groups. 4. Regarding the bacteriological effect, the eradication rates of both groups were over 90% on day 1 and after treatment. There was no significant difference between the 2 groups. 5. Side effects occurred in 1 case (2.6%) out of 39 in the CZOP group and in 1 case (2.4%) out of 41 in the CPR group. Laboratory test value fluctuation was noted in 8 (20.5%) of 39 cases in the CZOP group and 11 (26.8%) of 41 cases in the CPR group. There was no significant difference between the 2 groups. The results indicate that CZOP achieves an early efficacy to pyuria, and is as useful as CPR against compli-cated urinary tract infections.

A COMPARATIVE STUDY ON THE CLINICAL UTILITY OF CEFOZOPRAN AND CEFPIROME AGAINST COMPLICATED URINARY TRACT INFECTIONS

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