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- SUGITA RINYA
- Sugita Otorhinolaryngologic Clinic
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- DEGUCHI KOICHI
- Section of Studies, Tokyo Clinical Research Center
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- NAITO MASAO
- Naito Otorhinolaryngologic Clinic
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- NOMURA TAKAHIKO
- Nomura Otorhinolaryngologic Clinic
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- TANAKA MIKIO
- Tanaka Otorhinolaryngologic Clinic
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- WATANABE HIROSHI
- Department of Otorhinolaryngology, Taketani Hospital
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- HARADA SHINAKO
- Harada Dental and Otorhinolaryngologic Clinic
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- FUJIMAKI YUTAKA
- Fujimaki Otorhinolaryngologic Clinic
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- KOMATSU NOBUYUKI
- Komatsu Otorhinolaryngologic Clinic
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- OKANO KAZUHIRO
- Mihama Otorhinolaryngologic Clinic
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- SHIMIZU KOJI
- Shimizu Otorhinolaryngologic Clinic
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- KIMURA SHIGERU
- Kimura Otorhinolaryngologic Clinic
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- YOSHIDA YASUTOMO
- Yoshida Otorhinolaryngologic Clinic
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- SENBA TETSUO
- Senba Otorhinolaryngologic Clinic
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- UCHIDA TOSHIO
- Uchida Otorhinolaryngologic Clinic
Bibliographic Information
- Other Title
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- 小児急性化膿性中耳炎に対するclavulanic acid/amoxicillin投与症例の検討
- AMOXICILLIN IN PEDIATRIC ACUTE OTITIS MEDIA
- ペニシリン耐性肺炎球菌が原因菌であった症例を含む臨床的解析
Abstract
We carried out clinical and bacteriological studies on clavulanic acid/amoxicillin and amoxicillin in pediatricacute otitis media at 14general practice settings.The results are summarized as follows.<BR>1.The major isolated or ganisms from content of middle ear effusion were Streptococcus pneumoniae31.8%, Haemophilus influenzae35.8%and Moraxella subgenus Branhamella catarrhalis1.5%.Similar resultswere observed for the major isolates organisms from content of nasopharynx Streptococcus pneumoniae31.1%,Haemophilus influenzae33.9% and Moraxella subgenusBranhamella catarrhalis19.2%.<BR>2.42.2%of and pneumoniae isolated from middle ear effusion were drug resistant and pneumoniae (PISP, PRSP) and they were increasing year by year.<BR>3.46.7% of and pneumoniae isolated from nasopharyngeal swab were drug resistant S. pneumoniae (PISP, PRSP) and they were increasing year by year. The incidence of drug resistant S. pneumoniae isolated from allcases and organisms were26.3% and 145%, respectively.<BR>4.OnMIC90, antimicrobial activity of CVA/AMPC against Streptococcus pneumoniae,Haemophilus influenzae and Moraxella subgenus Branhamella catarrhalis was superior to SBTPC.<BR>5.In the evaluation of clinical efficacy, bacteriological efficacy and utility, CVA/AMPC-treated group wassignificantly superior to AMPC-treated group.<BR>6.Adverse reactions were observed in22%of CVA/AMPC-treated group, involving diarrhea and loose stool.
Journal
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- The Japanese Journal of Antibiotics
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The Japanese Journal of Antibiotics 52 (10), 595-612, 1999
Japan Antibiotics Research Association