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- NAKATA SHUJI
- Department of Pediatrics, Sapporo medical college
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- CHIBA SHUNZO
- Department of Pediatrics, Sapporo medical college
Bibliographic Information
- Other Title
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- 小児科領域におけるCefdinir細粒の体内動態と臨床的検討
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Description
A new oral cephem, cefdinir (CFDN) was evaluated for its efficacy, safety and pharmacokineticsin 13 children. The results are summarized as follows.<BR>Plasma concentration peaked at 3-4 hours after administration of 3 mg/kg of CFDN with Cmaxranging from 0.57-0.89 μg/ml except 1 case in which the absorption of the drug was poor.Recovery rates in urine averaged at 13.4%, with a large individual variation.<BR>Ten children with 12 bacterial infections were treated with 9 mg/kg/day of CFDN fine granule.Clinical responses were good in 10 patients and fair in 1 patient, with an efficacy rate of 90.9%. No clinical adverse reactions nor abnormal laboratory findings were encountered
Journal
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- The Japanese Journal of Antibiotics
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The Japanese Journal of Antibiotics 43 (10), 1789-1795, 1990
Japan Antibiotics Research Association
