COMPARATIVE STUDIES ON ACTIVITIES OF ANTIMICROBIAL AGENTS AGAINST CAUSATIVE ORGANISMS ISOLATED FROM URINARY TRACT INFECTIONS (1993)

Clinical background was investigated on 734 bacterial strains isolated from patients with urinary tract infections (UTIs) in 10 hospitals during the period from June, 1993 to May, 1994.<BR>1. Distribution of sex, age and infections<BR>Among over fifties males, the m ajority was taken by complicated urinary tract infections. Among females, the uncomplicated urinary tract infections was most frequent without a relation of age.<BR>2. Distribution of sex, age and pathogens isolated from UTIs<BR>In uncomplicated UTIs, Escherichia coli was most frequentl y isolated without a relation of age, and next Klebsiella spp. and CNS.<BR>In complicated UTIs wit hout indwelling catheter,E. coli and Enterococcus faecalis were the most frequent. In complicated UTIs with indwelling catheter, Pseudomonas aeruginosa were most frequently isolated, and next E. faecalis.<BR>3. The frequency of comple xed infections in UTIs<BR>The frequency of complexed infections has incre ased from in uncomplicated UTIs to complicated UTIs.<BR>4. Administration of antibiotics and pathogens isolated from UTIs<BR>In uncomplicated UTIs, pathogens, after administration of an tibiotics, isolated from patients have obviously decreased from 222 to 33 isolates. And also, pathogens of complicated UTIs without indwelling catheter, have decreased from 205 to 50 isolates. However, in complicated UTIs with indwelling catheter, pathogens after or before administration of antibiotics, were not revealed an obvious change.<BR>5. Pathogens and UTIs with or without factor and operation<BR>In uncomplicated UTIs with or without factor and op eration,E. coli was mainly detected. In complicated UTIs without indwelling catheter and with or without factor and operation,E. coli and E. faecalis were mainly detected. In complicated UTIs with indwelling catheter and with factor and operation,P. aeruginosa and E. faecalis were mainly detected, 22.0% and 14.1%, respectively. Without factor and operation, was detected,E. faecalis 21.1%, and next Proteus spp. 15.8%. The distribution of pathogens, in the case of Serratia spp., has been obviously varied by the influence of factor and operation.