COMPARATIVE STUDIES ON ACTIVITIES OF ANTIMICROBIAL AGENTS AGAINST CAUSATIVE ORGANISMS ISOLATED FROM URINARY TRACT INFECTIONS (1991)
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- KUMAMOTO YOSHIAKI
- Department of Urology, School of Medicine, Sapporo Medical College
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- HIROSE TAKAOKI
- Department of Urology, School of Medicine, Sapporo Medical College
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- TANAKA NORIAKI
- Department of Urology, School of Medicine, Sapporo Medical College
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- HIKICHI YOSHINAO
- Katta Polyclinic Hospital
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- SHIGETA SHIRO
- Department of Bacteriology, Fukushima Medical College
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- SHIRAIWA YASUO
- Department of Urology, Fukushima Medical College
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- KAMEOKA HIROSHI
- Department of Urology, Fukushima Medical College
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- YOSHIDA HIROSHI
- Department of Laboratory Medicine, Fukushima Medical College
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- OGATA MASAHIRO
- Department of Laboratory Medicine, Fukushima Medical College
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- TAZAKI HIROSHI
- Department of Urology, School of Medicine, Keio University
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- IRI HISAMI
- Central Clinical Laboratories, School of Medicine, Keio University
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- UCHIDA HIROSHI
- Central Clinical Laboratories, School of Medicine, Keio University
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- KOBAYASHI YOSHIO
- Central Clinical Laboratories, School of Medicine, Keio University
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- MATSUDA SEIJI
- Department of Gynecology, Koto Hospital
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- KITAGAWA RYUICHI
- Department of Urology, Juntendo University, School of Medicine
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- FUJIME MAKOTO
- Department of Urology, Juntendo University, School of Medicine
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- FUJITA KAZUHIKO
- Department of Urology, Juntendo University, School of Medicine
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- IGARI JUN
- Department of Clinical Pathology, Juntendo University, School of Medicine
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- OGURI TOYOKO
- Central Clinical Laboratories, Juntendo University
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- KOSAKAI NOZOMU
- Juntendo University Urayasu Hospital
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- YAMAGUCHI KEIZO
- Department of Microbiology, School of Medicine, Toho University
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- MOCHIDA CHIKAKO
- Department of Microbiology, School of Medicine, Toho University
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- FURUSAWA TARO
- Department of Urology, Kyoto Second Red Cross Hospital
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- TAKEUCHI YASUKO
- Central Clinical Laboratories, Kyoto Second Red Cross Hospital
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- MORIYAMA HIROMI
- Central Clinical Laboratories, Kyoto Second Red Cross Hospital
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- SHIBATA KIKUTARO
- Central Clinical Laboratories, Kyoto Second Red Cross Hospital
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- YONEZU SEIBUN
- The First Department of Internal Medicine, Kansai Medical University
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- TAKAHA MINATO
- Department of Urology, National Osaka Hospital
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- MATSUMIYA KIYOMI
- Department of Urology, National Osaka Hospital
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- TANAKA MICHIO
- Clinical Laboratories, National Osaka Hospital
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- KAKU MITSUO
- Department Laboratory, School of Medicine, Nagasaki University
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- SUGAWARA KAZUYUKI
- Department Laboratory, School of Medicine, Nagasaki University
Bibliographic Information
- Other Title
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- 尿路感染症分離菌に対する経口並びに注射用抗菌薬の抗菌力比較 (第13報1991年)
- I. SUSCEPTIBILITY DISTRIBUTION
- その1.感受性について
Abstract
The frequencies of isolation and susceptibilities to antimicrobial agents were investigated on 751 bacterial strains isolated from patients with urinary tract infections in 11 hospitals during the period of June 1991 to May 1992. Of the above total bacterial isolates, Gram-positive bacteria accounted for 28.6% and a majority of them were Enterococcus faecalis. Gram-negative bacteria accounted for 71.4% and most of them were Escherichia coli.<BR>1.Enterococcus faecalis<BR>Ampicillin (ABPC), imipenem (IPM) and vancomycin (VCM) showed the highest activities against E. faecalis isolated from patients with urinary tract infections. The MIC90s of them were 2μg/ml. Piperacillin (PIPC) and chloramphenicol (CP) were also active with the MIC90s of 8μg/ml. The others were not so active with the MIC90s of 32μg/ml or above.<BR>2.Staphylococcus aureus including MRSA<BR>Arbekacin (ABK) showed the highest activities against S. aureus isolated from patients with urinary tract infections. Its MIC90 was 0.5μg/ml. VCM was also active with its MIC90 of 1μg/ml. The others were not so active with the MIC90s of 32μg/ml or above.<BR>3.Citrobacter freundii<BR>Ciprofloxacin (CPFX) showed the highest activities against C. freundii isolated from patients with urinary tract infections. Its MIC90 was 0.5μg/ml. IPM, gentamicin (GM), ABK and norfloxacin (NFLX) were also active with the MIC90s of 1μg/ml. Penicillins and cephems were not so active.<BR>4.Enterobacter cloacae<BR>IPM showed the highest activities against E. cloacae isolated from patients with urinary tract infections. Its MIC90 was 0.5μg/ml. CPFX was also active with the MIC90 of 2μg/ml. Aminoglycosides were active comparatively. The MIC90s of them were 4μg/ml. Penicillins and cephems generally showed lower activities.<BR>5.Escherichia coli<BR>IPM and ciprofloxacin (CPFX) showed the highest activities against E. coli isolated from patients with urinary tract infections. The MIC90s of them were 0.125μg/ml or below. Flomoxef (FMOX), cefmenoxime (CMX), cefuzonam (CZON), latamoxef (LMOX), norfloxacin (NFLX) and ofloxacin (OFLX) were also active with the MIC90s of 0.25μg/ml. Penicillins except mecillinam (MPC) were not so active showing the MIC90s of 32μg/ml or above.<BR>6.Klebsiella pneumoniae<BR>IPM showed the highest activities against K. pneumoniae isolated from patients with urinary tract infections. Its MIC90 was 0.25μg/ml. Gentamicin (GM) and arbekacin (ABK) were also active with the MIC90s of 0.5μg/ml, respectively. But minocycline (MINO) and penicillins were not so active showing the MIC90s of 32μg/ml or above.<BR>7. Proteus mirabilis<BR>Most of the agents were active against P. mirabilis. Cephems except CEZ were generally active with the MIC90s in a range of ≤0.125μg/ml-2μg/ml. CRMN, NFLX, OFLX and CPFX were also active with the MIC90s of 0.125μg/ml or below. Penicillins were not so active.<BR>8.Pseudomonas aeruginosa<BR>Most of the agents were not so active against P. aeruginosa. IPM showed the MIC90 of 8μg/ml. CAZ, CRMN and AMK showed the MIC90s of 32μg/ml. IPM and TOB showed the MIC50s of 1μg/ml, 2μg/ml, respectively.<BR>9.Serratia marcescens<BR>Most of the agents were not so active against S. marcescens. Comparatively, IPM was active with the MIC90 of 2μg/ml. CAZ, CRMN and ABK showed the MIC90s of 16mu;g/ml. Penicillins and cephems except CAZ were not active showing the MIC90s of 64μg/ml or above.
Journal
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- The Japanese Journal of Antibiotics
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The Japanese Journal of Antibiotics 48 (10), 1394-1421, 1995
Japan Antibiotics Research Association