CLINICAL STUDIES ON EFFECT OF CEFBUPERAZONE ON SURGICAL INFECTIONS

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  • 外科領域の感染症に対するCefbuperazoneの有効性に関する検討

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Abstract

We conducted clinical studies on the efficacy and safety of cefbuperazone (CBPZ) on surgical infections with the following results.<BR>1) In evaluable 32 patients, CBPZ was evaluated to be clinically effective in 23 (71.9%) and the efficacy rate was better in those who were administered 4g/day of CBPZ (87.5%, 14/16) than in those who were given 2g/day (57.1%, 8/14).<BR>2) Antibacterial activity of CBPZ was evaluated in 41 isolated bacterial strains. Pathogen eradication rate by bacterial species was 75.6% (31/41). CBPZ exerted excellent antibacterial effects on Escherichia coli (100%, 8/8) and anaerobic bacteria such as Bacteroides (88.9%, 8/9). Resistant bacteria to CBPZ were Enterococcus faecalis and Pseudomonas aeruginosa.<BR>3) No serious side effects were noted in any of the 34 patients who entered in this study. Abnormal laboratory test results were noted in 2 patients (5.9%) and they were transient elevation of transaminases and alkaline phosphatase.<BR>From the results shown above, CBPZ appears to be a highly useful antibiotic for the treatment of surgical infection.

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