Experimental study on the ototoxicity of an anti-fungal agent (Lanoconazole, ASTAT® solution)

DOI
  • TAKUMIDA Masaya
    Department of Otolaryngology, Hiroshima University, School of Medicine
  • YAJIN Kouji
    Department of Otolaryngology, Hiroshima University, School of Medicine

Bibliographic Information

Other Title
  • 抗真菌剤 (ラノコナゾール, アスタット液®) 鼓室内投与による内耳障害の検討

Description

In order to apply the newly developed anti-fungal agent to ototmycosis, the ototoxicity of lanoconazole (ASTAT solution) was investigated using electron microscopy. The intratympanic injection of 2 and 1% lanoconazole in solvent as well as solvent alone caused a scattered loss of sensory hairs in the organ Corti as well as in the vestibular end organs of the guinea pig. This degeneration was most marked 24 hrs after the last injection but slightly recovered after 7 days. The loss of sensory hairs was a characteristic finding due to the vulnerability of the sensory hairs induced by ethanol which was used as the solvent. Lanoconazole itself may thus be regarded as nonototoxic. Since the application of lanoconazole as an ear drop has revealed no ototoxicity, lanoconazole may thus be applied as an effective drug for the treatment of otomycosis without causing any tympanic membrane perforation.

Journal

Keywords

Details 詳細情報について

  • CRID
    1390001205498086912
  • NII Article ID
    130004404318
  • DOI
    10.11334/jibi1954.43.2_178
  • ISSN
    04477227
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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