Clinical investigation of R 50547 (Levocabastine hydrochloride) nasal spray in perennial allergic rhinitis
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- OKUDA Minoru
- Japan Asthma and Allergy Clinic
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- TORIYAMA Minoru
- Department of Otorhinolaryngology, International National Medical Center of Japan
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- USAMI Atsushi
- Department of Otorhinolaryngology, Hamamatsu Medical Center
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- SEKITANI Toru
- Department of Otorhinolaryngology, Shimonoseki National Hospital
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- MOGI Goro
- Department of Otorhinolaryngology, Medical College of Oita
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- YOSHIMURA Osamu
- Department of Otorhinolaryngology, Sapporo City Hospital
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- YAGI Toshiaki
- Department of Otorhinolaryngology, Nippon Medical School
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- OKUBO Kimihiro
- Department of Otorhinolaryngology, Nippon Medical School
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- ONISHI Masaki
- Department of Otorhinolaryngology, Nippon Medical School
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- YOKOSHIMA Kazuhiko
- Department of Otorhinolaryngology, Nippon Medical School
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- OTSUKA Hirokuni
- Department of Otorhinolaryngology, Dai)ni Hospital, Nippon Medical School
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- MEZAWA Akinori
- Department of Otorhinolaryngology, Hakujikai Memorial General Hospital
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- IKEDA Masakazu
- Department of Otorhinolaryngology, Shitaya Hospital
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- MORIZONO Tetsuji
- Department of Otorhinolaryngology, Yatsu Insurance Hospital
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- MASUDA Tetsuya
- Department of Otorhinolaryngology, International National Medical Center of Japan
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- SHIMIZU Hironari
- Department of Otorhinolaryngology, International National Medical Center of Japan
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- FUNASAKA Sotaro
- Department of Otorhinolaryngology, Tokyo Medical College
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- SAITO Yoshimitsu
- Department of Otorhinolaryngology, Tokyo Medical College
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- TEI Seishu
- Department of Otorhinolaryngology, Tokyo Medical College
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- ARAI Masayuki
- Department of Otorhinolaryngology, Hachioji Medical Center, Tokyo Medical College
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- KAWAI Makoto
- Department of Otorhinolaryngology, Kasumigaura Hospital, Tokyo Medical College
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- SAEKI Tetsuro
- Department of Otorhinolaryngology, Kosei Central Hospital
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- KOIZUMI Rikako
- Department of Otorhinolaryngology, Kosei Central Hospital
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- UEDA Hiroshi
- Department of Otorhinolaryngology, Kamata General Hospital
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- TOKASHIKI Ryoji
- Department of Otorhinolaryngology, Meitokukai General Shinkawahashi Hospital
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- NAGASE Shigeyo
- Department of Otorhinolaryngology, Tokokai Toda Central General Hospital
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- OTSUKA Yoshiyuki
- Department of Otorhinolaryngology, Warabi City Hospital
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- ZUSHO Hiroyuki
- Department of Otorhinolaryngology, Kanto Rosai Hospital
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- ISHII Toyota
- Department of Otorhinolaryngology, Sagamihara National Hospital
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- YAJIMA Hiroshi
- Department of Otorhinolaryngology, Shizuoka Saiseikai General Hospital
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- TAKIMOTO Isao
- Department of Otorhinolaryngology, Aichi Medical University, School of Medicine
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- HORI Mizuyo
- Department of Otorhinolaryngology, Aichi Medical University, School of Medicine
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- IWASAKI Hiroshi
- Department of Otorhinolaryngology, Toki City Hospital
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- KORIYAMA Tomoya
- Department of Otorhinolaryngology, Toki City Hospital
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- YAMADA Kazumi
- Department of Otorhinolaryngology, Nagoya Ekisaikai Hospital
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- TSUJIMOTO Shigeru
- Department of Otorhinolaryngology, Asahi Rosai Hospital
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- KOBAYASHI Kayoko
- Department of Otorhinolaryngology, Gifu Koseiren Showa Hospital
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- NIWA Hideto
- Department of Otorhinolaryngology, Nagoya National Hospital
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- SATO Masahiro
- Department of Otorhinolaryngology, Nagoya National Hospital
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- TAKAHASHI Hiroaki
- Department of Otorhinolaryngology, Osaka Medical College
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- INOUE Isao
- Department of Otorhinolaryngology, Osaka Medical College
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- KAWAKAMI Yoshio
- Department of Otorhinolaryngology, Saiseikai Nakatsu Hospital
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- WADA Kohei
- Department of Otorhinolaryngology, Hirakata City Hospital
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- KUMOI Takeo
- Department of Otorhinolaryngology, Hyogo College of Medicine
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- SATOMI Fumio
- Department of Otorhinolaryngology, Hyogo College of Medicine
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- FUJIKI Hiroya
- Department of Otorhinolaryngology, Takarazuka City Hospital
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- DATE Kazuhiro
- Department of Otorhinolaryngology, Hyogo Prefectural Awaji Hospital
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- YOSHIMURA Shiro
- Department of Otorhinolaryngology, Ashiya City Hospital
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- ENOMOTO Tadao
- Department of Otorhinolaryngology, Wakayama Red Cross Hospital
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- SAKODA Takema
- Department of Otorhinolaryngology, Wakayama Red Cross Hospital
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- YANAGIHARA Naoaki
- Department of Otorhinolaryngology, Ehime University, School of Medicine
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- KIKUCHI Takashi
- Department of Otorhinolaryngology, Ehime University, School of Medicine
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- ARITOMO Hiroshi
- Department of Otorhinolaryngology, Matsuyama Red Cross Hospital
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- NAKAMURA Koshiro
- Department of Otorhinolaryngology, Ehime Prefectural Central Hospital
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- MASUDA Yu
- Department of Otorhinolaryngology, Okayama University, School of Medicine
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- OMICHI Takuya
- Department of Otorhinolaryngology, Okayama University, School of Medicine
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- TAKEHISA Toru
- Department of Otorhinolaryngology, Tsuyama Central Hospital
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- NAKATA Michihiro
- Department of Otorhinolaryngology, Tsuyama Central Hospital
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- SAITO Chisato
- Department of Otorhinolaryngology, Okayama City Hospital
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- ORITA Yozo
- Department of Otorhinolaryngology, Kawasaki Medical College
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- HAYASHI Takumi
- Department of Otorhinolaryngology, Sato Memorial Hospital
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- NISHIOKA Keiko
- Department of Otorhinolaryngology, Hiroshima City Hospital
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- TAKAHASHI Masahiro
- Department of Otorhinolaryngology, Yamaguchi University, School of Medicine
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- IMATE Yuji
- Department of Otorhinolaryngology, Yamaguchi University, School of Medicine
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- HIYOSHI Masaaki
- Department of Otorhinolaryngology, Yamaguchi Prefectural Central Hospital
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- MORIYA Keiji
- Department of Otorhinolaryngology, Nagato General Hospital
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- OKUZONO Tatsuya
- Department of Otorhinolaryngology, Shimonoseki National Hospital
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- OGAWA Nobuya
- Department of Pharmacology, Ehime University School of Medicine
Bibliographic Information
- Other Title
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- R50547(Levocabastine hydrochloride)点鼻剤の通年性アレルギー性鼻炎に対する臨床的効果
- phase III comparative trial with Sodium Cromoglicate
- クロモグリク酸ナトリウム点鼻剤との比較試験
Description
The efficacy and safety of a 0.025% R50547 nasal spray q. i. d.(L group) were assessed in 233 patients with perennial allergic rhinitis, by a single-blind comparative study using a 2% sodium cromoglicate nasal spray six times daily (S group). In the final global improvement rating, L group showed significantly higher improvement than S group (U test: p<0.05). The rates of “moderately improved” or better were 60.2% in L group and 45.4% in S group, with a 15% difference being demonstrated. In the overall safety rating, there was no statistic difference between the two administration groups. With regard to the global utility rating, based on the results of final global improvement rating and overall safety rating, L group demonstrated a significantly higher usefulness rate than S group (U test: p<0.05). Based on the above results, it is concluded that R50547 provides superior clinical efficacy to sodium cromoglicate, while it shows the same high level of safety in the treatment of perennial allergic rhinitis
Journal
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- OTOLOGIA FUKUOKA
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OTOLOGIA FUKUOKA 41 (2Supplement1), 381-403, 1995
JIBI TO RINSHO KAI
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Keywords
Details 詳細情報について
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- CRID
- 1390001205499064320
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- NII Article ID
- 130004404149
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- ISSN
- 04477227
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed
