Comparison of Urine Volume, Glomerular Filtration Rate, Excretion and Fraction of Reabsorption of Major Substances in Urine in Three Different Rat Strains

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  • 3系統のラットにおける尿量, 糸球体濾過量, 主要成分の尿中排泄量および再吸収分画の比較
  • 3 ケイトウ ノ ラット ニ オケル ニョウリョウ シキュウタイ ロカリョウ

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Abstract

Urine volume (UV), Glomerular filtration rate (GFR) and Fraction of reabsorption (FR) of water, Ca, IP, Na+, K+, Cl-, Glu and UN, which are significant in kidney function analysis, were investigated and compared in three rat strains (WI, SD and F344) . UV/body weight ratios were higher in SD rats as compared to other strains. The GFR difference was not significant, but the FRH2O difference was significant in three rat strains. FR of Ca, K+ and Glu showed no significant differences in three different rat strains. SD and F344 were significantly lower than WI in FR of IP. FR of Na+, Cl- and UN were significantly different in three rat strains without Cl- between SD and F344, and UN between WI and SD.

Journal

  • Experimental Animals

    Experimental Animals 43 (2), 167-172, 1994

    Japanese Association for Laboratory Animal Science

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