Pathology of Spontaneous Malignant Fibrous Histiocytoma in a Japanese White Rabbit

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  • 日本白色種ウサギの自然発生悪性線維性組織球種の病理学的所見

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Spontaneous malignant fibrous histiocytoma (MFH) of the chest wall was found in a 10-year-old male Japanese white rabbit. Histologically, the MFH consisted mainly of areas of storiform, pleomorphic and myxoid patterns. Positive reactions for acid phosphatase (Ac-P), non-specific esterase (N-SE) and β-glucuronidase (β-GL) were demonstrated in fibroblast-like, histiocyte-like and giant cells. Moreover, a strongly positive fibronectin (FN) reaction was observed mainly in histiocyte-like and giant cells. In electron microscopy, tumor cells were composed morphologically of various types of cells such as fibroblast-like, histiocyte-like, undifferentiated and giant cells. This case was quite similar to those reported in man or other animals.

Journal

  • Experimental Animals

    Experimental Animals 38 (2), 165-169, 1989

    Japanese Association for Laboratory Animal Science

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