Susceptibility of Four Species of Small Rodents to Encephalomyocarditis (EMC) Virus Infection

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  • MATSUZAKI Hitoshi
    <I>Department of Biomedical Science, Faculty of Agriculture, The University of Tokyo</I>
  • DOI Kunio
    <I>Department of Biomedical Science, Faculty of Agriculture, The University of Tokyo</I>
  • DOI Chiyo
    <I>Department of Biomedical Science, Faculty of Agriculture, The University of Tokyo</I>
  • ONODERA Takashi
    <I>Laboratory of Immune Cytology, National Institute of Animal Health</I>
  • MITSUOKA Tomotari
    <I>Department of Biomedical Science, Faculty of Agriculture, The University of Tokyo</I>

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Other Title
  • 4種の小型げっ歯類の脳心筋炎ウイルスに対する感受性
  • 4種の小型げっ歯類の脳心筋炎ウイルスに対する感受性〔英文〕
  • 4シュ ノ コガタ ゲッシルイ ノ ノウ シン キンエン ウイルス ニ タイス

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Abstract

The D variant of encephalomyocarditis virus (101-105 PFU/head) was intraperitoneally inoculated into 4 species of small rodents, rats, mice, Syrian hamsters, and Mongolian gerbils, and the susceptibillity of these animals to EMC virus was examined virologically and histopathologically 3 days after infection. Viral replication was detected in the brain (mice), in the heart (mice and gerbils), and in the pancreas (mice, hamsters, and gerbils) . No viral replication was detected in rats. Histopathological changes were seen in the brain (mice and hamsters), in the heart (mice and gerbils), and in the pancreas (mice, hamsters, and gerbils) . No histopathological changes were seen in rats. The present results suggest that it may be quite passible to produce EMC virus-induced diabetes mellitus not only in mice but also in hamsters and gerbils.

Journal

  • Experimental Animals

    Experimental Animals 38 (4), 357-361, 1989

    Japanese Association for Laboratory Animal Science

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