Sero-Epidemiological Observation on Mouse Hepatitis Virus in a Mouse Breeder Colony

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  • IWAI Hiroshi
    <I>Department of Microbiology, Central Institute for Experimental Animals</I>
  • ITO Toshio
    <I>Department of Microbiology, Central Institute for Experimental Animals</I>
  • YAMANAKA Junko
    <I>Department of Microbiology, Central Institute for Experimental Animals</I>
  • ISHIHARA Yasuko
    <I>Department of Microbiology, Central Institute for Experimental Animals</I>
  • SHUMIYA Seigo
    <I>CLEA Japan, Inc.</I>

Bibliographic Information

Other Title
  • マウス繁殖コロニーにおけるマウス肝炎ウイルスの血清疫学的観察
  • マウス ハンショク コロニー ニ オケル マウス カンエン ウイルス ノ ケッセイエキガクテキ カンサツ

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Description

Mice from a breeder corony producing 6, 000 mice per week were examined for complement fixing antibody against mouse hepatitis virus (MHV) by anamnestic response. Just before the first antibody detection in retired breeder mice, a decrease in weaning rate was observed, but it recovered with increase in antibody positivity in retired breeders. Thereafter, the antibody was detected at monthly monitering in them for over 3 years and the positive rate and titer showed a cyclic variation of 7 or 8 months. Mice weaned at a time when the positivity of retired breeder mice was comparatively high had no detectable antibody at 3 of 4 weeks of age, but 21 to 26% of those of age 5 or 6 weeks had the antibody. Even when such mice as mentioned above were isolated from the infected colony into a MHV-free environment at 3 or 4 weeks of age, the antibody also appeared later in their sera. However, when pregnant mice having been exposed naturally to MHV infection were isolated intoa MHV-free environment before belivery, their progenies were found to have no detectable antibody at 6 to 10 weeks of age, while antibody became detected in controls exposed to an infected environment. Although the antibody positive rate did not exceed 50% even at 8 to 14 weeks of age in mice weaned at a time when thepositive rate of retired breeders was comparatively high, the positivity reached 60% or more at age of 8 weeks or older but none of them died, when 4-week-old mice from a non-infected colony were housed in the infected one. Germf ree mice of 3 or 4 weeks of age directly or indirectly associated with feces of 5-week-old mice from the infected colony died at mortality of 25 to 64% and most of the survivals were shown to have antibody after one month.

Journal

  • EXPERIMENTAL ANIMALS

    EXPERIMENTAL ANIMALS 22 (4), 295-301, 1973

    Japanese Association for Laboratory Animal Science

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