<I>rdw</I> Rats, a New Hereditary Dwarf Model in the Rat

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  • KOTO Masao
    <I>Drug development laboratories, CHUGAI pharmaceutical Co., Ltd.</I>
  • SATO Tsuyoshi
    <I>Drug development laboratories, CHUGAI pharmaceutical Co., Ltd.</I>
  • OKAMOTO Michio
    <I>Drug development laboratories, CHUGAI pharmaceutical Co., Ltd.</I>
  • ADACHI Jiro
    <I>Drug development laboratories, CHUGAI pharmaceutical Co., Ltd.</I>

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Other Title
  • 新しい遺伝性侏儒症モデルラット (<I>rdw</I>)
  • 新しい遺伝性侏儒症モデルラット(rdw)
  • アタラシイ イデンセイ シュジュショウ モデル ラット rdw
  • Rdw rats, a new hereditary dwarf model in the rat

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Description

A new hereditary dwarf mutation was found in Csk: Wistar-Imamichi rat breeding colony. The mutant rats and control normal rats were studied with clinical, genetical and histological examination. The result showed that the present mutation was inherited in autosomal recessive trait (gene symbol; rdw) and was provoked with the hypoplasia of pars distalis (anterior pituitary), in particular the secretory cells of GH, PRL and TSH. The characteristics of the present mutant (rdw) was very similar to dw mouse, and was usefull for endocrinological research as an animal model of human pituitary dwarfism.

Journal

  • Experimental Animals

    Experimental Animals 37 (1), 21-30, 1988

    Japanese Association for Laboratory Animal Science

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