A New Polymorphic Pepsinogen Locus (<I>Pg-2</I>) in the Rat (<I>Rattus norvegicus</I>)

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  • HAMADA Shuichi
    <I>Institute of Laboratory Animals, Faculty of Medicine, Kyoto University</I>
  • YAMADA Junzo
    <I>Institute of Laboratory Animals, Faculty of Medicine, Kyoto University</I>
  • BENDER Klaus
    <I>Institute für Humangenetik und Anthropologie, Universität Freiburg</I>
  • ADAMS Mark
    <I>Evolutionary Biology Unit, South Australian Museum</I>

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Other Title
  • ラットにおけるpepsinogenの新しい多型遺伝子座 (<I>Pg-2</I>)
  • ラットにおけるpepsinogenの新しい多型遺子座(Pg-2)〔英文〕
  • ラット ニ オケル pepsinogen ノ アタラシイ タケイ イシザ Pg

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Abstract

Only two types of pepsinogens, which are products of the Pg-1 locus, are present in rat urine. In gastric mucosa, however, additional pepsinogen isozymes are expressed. We have found a polymorphism for rat gastric mucosa pepsinogen using agarose gel electrophoresis. Some inbred rat strains expressed a pepsinogen band, while others did not. The trait was found to be controlled by a single autosomal locus. We tentatively designated the locus as Pg-2 with two alleles, Pg-2a for the one controlling presence of the band and Pg-2o for the one controlling absence. Linkage analysis using BN and TM strains revealed that Pg-2 was closely linked to Pg-1 (3.7±1.8cM), and that it did not belong to LG I (Hbb and p), LG II (Aeon-1 and Mup-1), LG IV (Hao-1 and Svp-1), LG V (Es-1 and Es-3), LG VI (Gc and h), LG IX (RT1), LG X (Fh and Pep-3), nor a LG containing Ahd-2 (as yet undetermined) .

Journal

  • Experimental Animals

    Experimental Animals 36 (3), 267-272, 1987

    Japanese Association for Laboratory Animal Science

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