ALLOXAN DIABETES IN DIFFERENT STRAINS OF MICE

INO Takayoshi, YOSHIKAWA Sakio

doi:10.1538/expanim1957.15.3-4_97

This experiment was made to see whether susceptibility to alloxan differs among different strains of mice. Male mice of the CFW, CF1, C₃H, C₅₇BL, DDK, NC, KK, RR, SS, and AA strains of age approxi-mately 100-120 days were used. Alloxan was injected intravenously into the tail vein at a dose of 40, 60, 80 or 100mg/kg of body weight. The results demonstrated that susceptibility to alloxan is different among the strains of mice. The percentages of diabetics at the seventh day after injection of 40mg/kg in DDK and RR strains were 5.8% and 30.0%, respectively, while other strains did not show diabetes at this dose of alloxan. In animals injected with 60mg/kg, the percentages of diabetics at the seventh day after injection were 25.9% in CFW, 77.2% in CF1, 90.0% in C₃H, 50.0% in C₅₇BL, 56.6% in DDK, 0 % in NC, 30.0%in KK, 50.0% in RR, 53.8% in SS, 62.5% in AA respectively. At a dose of 80mg/kg, the incidences of diabetics at the seventh day after injection were of 100% in CF1, C₃H, SS strains, 80-90% in C₅₇BL, DDK, KK, RR and AA strains, 68% in CFW strain, and 9.0% in NC strain. At a dose of 100mg/kg, the percentage of diabetics in NC strain was 47.8%, while 80-100% in the other strains. The pattern of the percentage from the first day to the seventh day after injection showed different types between C₃H and NC strains. C₃H strain did not show diabetes at the first day but the percentage had been elevated since the second day in 60mg/kg, 80mg/kg and 100mg/kg groups. On the other hand, in NC strain the percentage of the second day was lower than that of the first day in 80mg/kg and 100mg/kg groups. The percentage of diabetics in other strains than C₃H and NC strains increased slowly with time after injection.

ALLOXAN DIABETES IN DIFFERENT STRAINS OF MICE

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