Establishment of a New Hereditary-cataract Mouse (CSM) Strain Derived from SENCAR Mouse

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  • SATO Tsuyoshi
    <I>Drug Development Laboratories, CHUGAI Pharmaceutical Co., Ltd.</I>
  • MIYAI Tatsuya
    <I>Drug Development Laboratories, CHUGAI Pharmaceutical Co., Ltd.</I>
  • AKAIKE Isamu
    <I>Drug Development Laboratories, CHUGAI Pharmaceutical Co., Ltd.</I>
  • TOGASHI Mamoru
    <I>Drug Development Laboratories, CHUGAI Pharmaceutical Co., Ltd.</I>
  • KOJIMA Misao
    <I>Drug Development Laboratories, CHUGAI Pharmaceutical Co., Ltd.</I>
  • OKAMOTO Michio
    <I>Drug Development Laboratories, CHUGAI Pharmaceutical Co., Ltd.</I>

Bibliographic Information

Other Title
  • SENCAR系マウスに見いだされた遺伝性白内障モデル (CSM系) について
  • SENCARケイ マウス ニ ミイダサレタ イデンセイ ハクナイショウ モデル

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Description

A mouse representing a new hereditary-cataract strain was found in a mouse colony and a new line was established strain CSM. These mice were investigated genetically, histologically and biochemically. The results suggested that this cataract was apparently inherited through two recessive autosomal genes. Histologically the denucleation process of lens fibers was abnormal and small vacuoles appeared in the equatorial region of the lens cortex at 12 days. Biochemically, insoluble protein and sodium increased in the lens with age.

Journal

  • Experimental Animals

    Experimental Animals 37 (4), 375-380, 1988

    Japanese Association for Laboratory Animal Science

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