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- MORIMOTO Junji
- <I>Second Department of Pathology, Nara Medical University</I>
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- IMAI Shunsuke
- <I>Second Department of Pathology, Nara Medical University</I>
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- TSUBURA Yoshihiko
- <I>Second Department of Pathology, Nara Medical University</I>
Bibliographic Information
- Other Title
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- 非近交ddマウスにおける乳癌ウイルス (MuMTV) 感染の実態
- 非近交ddマウスにおける乳癌ウイルス(MuMTV)感染の実態〔英文〕
- ヒ キンコウ dd マウス ニ オケル ニュウガン ウイルス MuMTV カン
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Description
The expression of mammary tumor virus (MTV) antigen in the milk and various organs of three non-inbred dd mouse stocks (ddO, ddN and ddY) was examined by the immunodiffusion (ID) and micro-immunodiffusion (micro-ID) tests. The rate of MTV antigen expression in the milk was 100% at the first lactation in dd0 (6/6) and ddN mice (10/10), and 23% in ddY mice (3/13) . Mammary tumor incidence was 13% (mean tumor age : 12.0 months), 32% (9.6 months) and 10% (11.5 months) in ddO, ddN and ddY mice, respectively. In F1hybrids between MTV-free BALB/c females and dd males, a high level of MTV antigen was detected by the ID test in the milk of (BALB/c×ddO) F1, however, the levels in (BALB/c×ddN) F1and (BALB/c×ddY) F1mice were low at the first lactation and elevated with the advance of lactation number. Mammary tumor incidence had a trend to be higher and earlier in these F1hybrids than in non-inbred dd stocks. The development of mammary tumors and detection of MTV antigen in F1hybrids indicate the extrachromosomal transmission of MTV by male dd mice. The micro-ID test has shown that the mammaty tumors, mammary glands, male genital organs except for the testis and the salivary gland expressed MTV antigen, with a high frequency of suggesting that secondary male genital organs may play an important role in MTV infection in mice.
Journal
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- Experimental Animals
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Experimental Animals 31 (2), 107-111, 1982
Japanese Association for Laboratory Animal Science
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Keywords
Details 詳細情報について
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- CRID
- 1390001205503088128
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- NII Article ID
- 130006134538
- 130005000348
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- NII Book ID
- AN00104954
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- ISSN
- 18817122
- 00075124
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- NDL BIB ID
- 2488000
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed